Discover and read the best of Twitter Threads about #proteaseinhibitor

Most recents (3)

Ensitrelvir or S-217622, a potent inhibitor of SARCov2 main protease from Japan shows activity against COVID19 Variants of concern in animals studies and is poised to enter clinical trials.
#COVID19 #Ensiltrevir #Japan #ProteaseInhibitor #S217622
science.org/doi/10.1126/sc…
Ensiltrevir blocks SARSCov2 Main protease after viral entry. #Ensiltrevir science.org/doi/10.1126/sc…
Prophylactic treatment of S-217622 controls viral burden and disease in hamsters inoculated with SARS-CoV-2
science.org/doi/10.1126/sc…
Read 6 tweets
@pfizer @POTUS @TheDemocrats @VP @CNN @CBSNews @NBCNews @WKRN @WSMV @NC5 I have had the amazing opportunity to sit on Vanderbilt's HIV/AIDS Clinical Trials Community Advisory board since 2015 and want to shine a bright light on how therapeutics with SARS-Cov-2 should have been managed in the same way as HIV.
@pfizer @POTUS @TheDemocrats @VP @CNN @CBSNews @NBCNews @WKRN @WSMV @NC5 During the early years of the HIV/AIDS crisis, many were without any options. Then, AZT and other handfuls of medications were made available. Those who took it were literally guinea pigs. While supposition, I imagine escaping hospitalization and death were the metrics used.
Read 24 tweets
In a world with #Omicron (a rare mutational event), the drug #molnupiravir (a mutagen) was just authorized by the @US_FDA despite:

1⃣ NO estimate of the number of mutations it causes per virus

2⃣ NO estimate of onward viral transmission while on the drug
fda.gov/news-events/pr…
@US_FDA Given #molnupiravir's usage to treat #COVID19 is inevitable, what can be done to prevent the potential acceleration of #SARSCoV2 variants?
1⃣patients should strictly ISOLATE WHILE TAKING, especially in the first days on the drug

2⃣ALL DOSES should be taken PRECISELY as directed
@US_FDA Our own reasons for these recommendations are presented here 👇
Read 5 tweets

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