Discover and read the best of Twitter Threads about #pyroptosis
Most recents (2)
"Caught on Tape: Immune Cells Migrating From the Gut to the Brain | Immunology"
May explain the S proteins in the brain of the vaccinated and lead to Neurodegenerative diseases, including prions in that group.
#pyroptosis
#GSDME
#gasdermin
#caspase
labroots.com/trending/immun…
May explain the S proteins in the brain of the vaccinated and lead to Neurodegenerative diseases, including prions in that group.
#pyroptosis
#GSDME
#gasdermin
#caspase
labroots.com/trending/immun…
"A set of 16 proteins that seems to control the onset of the Prions disease. Interestingly, almost all of these proteins have known functions in neuro-inflammation."
"Brain inflammation likely key initiator of Prion and Parkinson’s diseases" wwwfr.uni.lu/lcsb/news_even…
"Brain inflammation likely key initiator of Prion and Parkinson’s diseases" wwwfr.uni.lu/lcsb/news_even…
A 2012 published study.
"Our analysis supports the hypothesis that sustained brain inflammation is the main pathogenic process leading to neuronal dysfunction and loss, which, in turn, leads to clinical symptoms in prion disease."
bmcsystbiol.biomedcentral.com/articles/10.11…
"Our analysis supports the hypothesis that sustained brain inflammation is the main pathogenic process leading to neuronal dysfunction and loss, which, in turn, leads to clinical symptoms in prion disease."
bmcsystbiol.biomedcentral.com/articles/10.11…
Several studies are coming out saying that blood LDH (lactate dehydrogenase) levels early in #COVID19 disease correlates with severe disease progression. This is a clue that #pyroptosis may be a the core of this disease (1/n).
medrxiv.org/content/10.110…
jci.org/articles/view/…
medrxiv.org/content/10.110…
jci.org/articles/view/…
What is LDH? It is an enzyme found within the cytosol of nearly all cells. Ed Miao's group showed that LDH release is a reliable way to monitor #pyroptosis, a form of cell death that depends on inflammasomes leading to plasma membrane rupture. (2/n)
ncbi.nlm.nih.gov/pubmed/23852598
ncbi.nlm.nih.gov/pubmed/23852598
LDH is not released by apoptosis or even hyperactivation of macrophages. It requires pyroptosis and membrane rupture shown by @jkagan1 's group. (3/n)
sciencedirect.com/science/articl…
sciencedirect.com/science/articl…
