Discover and read the best of Twitter Threads about #radbio

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1/n

💊How to best combine targeted agents with #radiotherapy☢️

Ch4⃣from our book
springer.com/us/book/978303…

Biomarkers of clinical radioresistance. Great pleasure to have written this one with @max_diehn @michaelsbinkley Iris Eke @StanfordRadOnc🙏

#radonc #radbio #RTdrugcombo
2/n

As @SorenBentzen keeps saying, absolute radioresistance does not exist. You just have to up the dose💪

That is very different from drug response, which is a yes/no situation - where more drug does not give you typically a better response (with caveats 😉)

#radonc #radbio
3/n

Tumors can have variable radioresistance. Lab & human data indicate that relationship between dose + tumor eradication is sigmoid🚨

Really high doses are prohibited by tolerance of normal tissue surrounding the tumor‼️

= Rationale for pursuing targeted radiosensitizers💡
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