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Do the benefits outweigh the risks in using MRI gadolinium-based contrast media (GBCM) in patients with kidney disease?
MAJOR new consensus statement from @RadiologyACR and @NKF published in @Radiology_RSNA at doi.org/10.1148/radiol…
A #RadInTraining #TWEETORIAL thread 👇
MAJOR new consensus statement from @RadiologyACR and @NKF published in @Radiology_RSNA at doi.org/10.1148/radiol…
A #RadInTraining #TWEETORIAL thread 👇
BACKGROUND:
GBCMs consist of gadolinium ions chelated with organic ligands to minimize toxicity from free gadolinium.
Which chemical class has a lower rate of free gadolinium dissociation?
GBCMs consist of gadolinium ions chelated with organic ligands to minimize toxicity from free gadolinium.
Which chemical class has a lower rate of free gadolinium dissociation?
Answer: Macrocyclic GBCMs are more stable (lower ratio of free gadolinium to complexed ligand). (Remember, 𝐋inear is 𝐋abile)
Macrocyclics form a complete ring, whereas linear agents form an incomplete ring.
Examples:
Macrocyclics form a complete ring, whereas linear agents form an incomplete ring.
Examples:
