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Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3…
Substantial upregulation of 5-HT2A after just 6–8 hrs

5-HT2A also mediate the hallucinogenic effects of psychedelic drugs


Post-mortem data shows reduced EGR3 and 5-HT2A in the prefrontal cortex of schizophrenics vs. controls, implying that the upregulation is compensatory and due to low binding ability.
The post-mortem schizophrenic patients showed 6 antibodies indicating immunoreactivity, specifically in the brain, against histone proteins.

"Each of the 6 antihistone antibodies resulted in robust immunoreactivity of nuclei in the prefrontal cortex"
Read 5 tweets
Virgin coconut oil as the main fat source in a diet of 60% fructose, 20% protein, 10% fat maintains redox status and markedly improves glucose metabolism "Variation in the glucose tolerance of animals under th
When animals are fed the same diet but with copra oil instead, they develop insulin resistance and advanced fatty liver.

Both oils are composed of over 90% of the beneficial MCTs, so the 2-fold higher antioxidant polyphenols in virgin coconut oil seem to make the difference. VCO = virgin coconut oil CO = copra oil
60% fructose + 10% fat as copra oil led to a 46% blood sugar increase and higher oxidative stress

60% fructose + 10% fat as virgin coconut oil only raised blood glucose by 16%, significantly increased glutathione and antioxidant enzymes, and reduced lipid peroxidation.
Read 5 tweets

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