Discover and read the best of Twitter Threads about #receptor
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For centuries we've had anatomical maps of how the body's organs are connected, but what would a diagram of the immune system’s connections look like? In @Nature we report our initiative to map the "interactome" that links human immune cells together (1/14)nature.com/articles/s4158… 
The life of an immune cell is constantly on the move. As white blood cells (leukocytes) circulate throughout the body, they must dynamically form connections with each other in order to communicate messages like “threat detected!” or “stop attacking, this is healthy tissue”(2/14)
Leukocytes can physically interact through #receptor proteins on their surfaces that have evolved to recognize and bind each other. These receptor interactions have enormous medical significance, to cite the #immuntherapy revolution in cancer treatment as just one example (3/14)
😮! These findings significantly expand on a central mechanism by which persistent #pathogens drive chronic disease 👉 Namely, the ability of intracellular pathogens to dysregulate host receptor actvity in a manner that alters downstream pathway signaling: stke.sciencemag.org/content/12/599…
