Discover and read the best of Twitter Threads about #reduceit

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#ACC21

Nice work #STRENGTHTrial team! #OM3

First - primary endpoints not achieved. This is a sub-study.

Questions attempted to address:
- Could higher EPA explain favorable outcomes?

- Could DHA component have exactly counterbalanced benefits of EPA?

1/
#ACC21
Recall #STRENGTHtrial randomized 13,000+. Similar MACE outcomes to #REDUCEIT.

STRENGTH sub-study looks at top tertile achieved EPA and DHA compared to corn oil.'
2/
#ACC21

-Interesting that high intensity statin use in top tertile was 10% less than other tertiles and corn oil group.

-LDL-C was 7 mg/dL higher in top tertile group than next highest (T1)

-Achieved EPA (443%) and DHA (68%) is c/w with dose 2200 mg, 800 mg respectively

3/
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