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Why do some pts with renal cell carcinoma present w/ polycythemia🩸vs others w/anemia🤔?
1/ Erythropoietin (EPO)➡️glycoprotein that induces differentiation of erythrocytes in the bone marrow to promote RBC production➡️produced in the KIDNEY
1/ Erythropoietin (EPO)➡️glycoprotein that induces differentiation of erythrocytes in the bone marrow to promote RBC production➡️produced in the KIDNEY
In RCC➡️EPO is produced ectopically by RCC tumor cells causing abnormalities in RBC production
🧐In fact‼️ ectopic EPO occurs in 66% of RCC pts!
Despite high concentrations of EPO➡️Anemia (⬇️RBC) is common due to poor nutrition🍎, hematuria🩸 or ineffective erythropoiesis🛑
🧐In fact‼️ ectopic EPO occurs in 66% of RCC pts!
Despite high concentrations of EPO➡️Anemia (⬇️RBC) is common due to poor nutrition🍎, hematuria🩸 or ineffective erythropoiesis🛑
Polycythemia➡️less common in 1-5% of pts, most common in clear cell RCC is due to paraneoplastic production of EPO results in excess RBC and reduction in inhibitory proteins that haunt RBC production!
pubmed.ncbi.nlm.nih.gov/2297568/
#oncopharm
#twitterx #OTILT #renalcellcarinoma #rcc
pubmed.ncbi.nlm.nih.gov/2297568/
#oncopharm
#twitterx #OTILT #renalcellcarinoma #rcc
