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1/ [ 5th AMIB-ESICM Symposium]:
I talked about the physiological rationale of the #HFNC for hypercapnic ARF.
So not all hypercapnic ARF are the same. There are those due to Central hypoventilation / neuromuscular disorders & those due to V/Q mismatch
@israelmaia16 @RENOVATEtrial
2/ In the V/Q mismatch category, airway diseases such as #COPD commonly presents a mismatch due to ⬆️Vd/Vt. And how that happens can be easily appreciated in these two slides:
3/ Dead space (Vd) is composed by:
- anatomical dead space (fixed)
- alveolar dead space (which can vary)

When we think on the potential effect of the HFNC for hypercapnic ARF, it´s probable that the greatest benefits will b seen on hypercapnia due to ⬆️Vd/Vt, and the reason is:
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