Discover and read the best of Twitter Threads about #reproducible

Most recents (6)

🧵🧵 THREAD: 10 reasons why #bioinformaticians should use #Nextflow 🧵🧵
1. #Nextflow is an open-source platform for #bioinformatics #pipelines and #workflows, designed to make them #scalable, #reproducible, and #portable.
2. #Nextflow allows #bioinformaticians to write their #pipelines and #workflows in a simple and expressive domain-specific language, called #Nextflow Script.
Read 11 tweets
🎉New preprint! @LauraKremer20 and I looked at four different gene knockouts in mt.5024C>T mice to investigate how #autophagy affects #mtDNA heteroplasmy inheritance.…
@MRC_MBU @cam_mito @mitopinionated 🧵: 1/
To what extent is germline purifying selection driven by autophagy? We looked at the mother-to-pup heteroplasmy shift in high-heteroplasmy mice carrying Parkin, Bcl2l13, Ulk1, and Ulk2 knockouts, as well as two separate control populations. 2/ Overview of the experimenta...
While previously Filograna et al. (2019) @RobertaFilogra2 show TFAM overexpression can lead to higher maximal tolerated heteroplasmy, this was not the case for our autophagy knockouts. We saw no knockout mice with H>80%, despite having 120+ pups in each group. 3/
Read 10 tweets
Finally, the #GoldacreReview is published! (During Parliamentary Easter holidays, mid-ping-pong on the #HealthAndCareBill...)

It's 221 pages - each PDF page is a double page spread - so this could be a lo-o-o-ong [Thread].

Here goes...
First point to note, in the Terms of Reference (p5), is that this is about "access to #NHSdata by #researchers, #commissioners, and #innovators" - i.e. #Planning and #CommercialReUse - so it is directly relevant to the operation of millions of people's #NationalDataOptOuts... Terms of reference for the review  1. How do we facilitate a
"185 wide-ranging recommendations for us to explore", says @sajidjavid (p6). Gulp! Time for some coffee...

"systems that ensure #underrepresented groups are well represented" may (partly) refer to this "landmark review", which got off to a slow start:… The far-reaching independent review into potential ethnic bi
Read 159 tweets
I am delighted that, after years of collaborative and interdisciplinary efforts, our work is finally out…
A joint effort with a wonderful team of colleagues (@ico2s , @portabolomics) spanning software engineering (@nocoffeenocode), synthetic biology & environmental microbiology (@vdlorenzo_CNB) and social sciences (@LPelechova , @PEALSncl )
We take a small but important step in developing tools for #OpenScience and more #reproducible strain engineering.
Read 8 tweets
Fresh thread to intersect other three threads on scientific nature of research: Read on
How reproducible is a research work of the Mahabharata?
Can it be reproduced as people say or is that not true?
Let us see.
First we have to ask:
How does someone reach a year like 5561BCE for their year of the Mahabharata?
Is it because of the triangulation of Jupiter or Saturn or indeed Mars?
For example in 3067BCE we have a biangulation of Saturn at Rohini (137 points )and Mars retrograde before reaching Jyestha/Anuradha (brings it down to 19 points) and then lunar eclipse precedes solar eclipse to bring it down to two points.
Can 5561BCE reproduce this sort of path?
Read 13 tweets
I didn't know you can use #rstats to make #reproducible conference posters! Cool and useful! Would love to see some examples!
Ah, there's a showcase of examples here:…
Here's one example, looks pretty comparable to making it in PowerPoint, keynote or illustrator:…
Read 4 tweets

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