Discover and read the best of Twitter Threads about #residualdisease
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Happy to announce our latest publication is online!
rdcu.be/c1f58
Huge effort from @ashkanshahbandi and co authors @Raegan2222 @SelinaSMJ_here @AshlynA_99 @LabMachado @Lorax_Bodyspray @Thesrao
#cancer #breastcancer #Immunotherapy #SABCS2022
a quick 🧵 tweetorial...
rdcu.be/c1f58
Huge effort from @ashkanshahbandi and co authors @Raegan2222 @SelinaSMJ_here @AshlynA_99 @LabMachado @Lorax_Bodyspray @Thesrao
#cancer #breastcancer #Immunotherapy #SABCS2022
a quick 🧵 tweetorial...
@ashkanshahbandi was interested in examining why some BC have residual disease after chemo Rx that persists. These tumors tend to be p53 wild type and tend to undergo cell cycle arrest/senescence rather than cell death #chemotherapy #residualdisease
Looking at immune regulatory pathways he found PD-L1 and CD80 were both highly induced in tumors from chemotherapy treated mice. By RNA, many checkpoints were induced in senescent human BC and mouse mammary tumors after chemo (Fig.1)
