Discover and read the best of Twitter Threads about #retroelements
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Ever wondered if and how #recombination of #retroelements contributes to #somatic #mosaicism? Read about it in our new pre-print:
Non-allelic homologous recombination of Alu and LINE-1 elements generates somatic complexity in human genomes. biorxiv.org/content/10.110…
Non-allelic homologous recombination of Alu and LINE-1 elements generates somatic complexity in human genomes. biorxiv.org/content/10.110…
1/ Background: pathogenic non-allelic homologous recombination (NAHR) of Alu and LINE-1 has been found in several genomic disorders and #cancer types. We thought this could be just the tip of the iceberg of a physiological recombinogenic activity of retroelements.
2/ The excellent Martin Frith developed a fresh pipeline to identify non-allelic homologous recombination (NAHR) in short and long-reads libraries: 🦖TE-reX🦖. It smartly focuses on split reads that join repeat elements at homologous positions. 
