Discover and read the best of Twitter Threads about #reversegenetics

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#Shi & her 2022 #China Patent: BALB/c mouse adapted strain of #SARS related coronavirus WIV1-RsSHC014S and application thereof..
Inventors: Shi Zhengli, Lin Haofeng, Liu Meiqin, Jiang Rendi
Zhou Peng. #WIV1 #RsSHC014S Image
The invention relates to the technical field of coronavirus, in particular to a BALB/c mouse adapted strain of SARS-related coronavirus WIV1-RsSHC 014S. Image
The SARS-associated coronavirus #RsSHC014 can effectively replicate and propagate in a corresponding cell line and a transgenic mouse by using #hACE2 as a receptor, Image
Read 62 tweets
"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..." ImageImageImage
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964 ImageImageImageImage
In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily. ImageImageImageImage
Read 68 tweets

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