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Inspired by the @CPSolvers #RLR episode released earlier this week, I wanted to share a bit about myopathy associated with statins and with red yeast rice.
Functioning as hmg-coa reductase inhibitors, statins are effective in reducing serum cholesterol levels but are proposed to be associated with myalgias and myopathies by various mechanisms as a direct result of decreased synthesis of mevalonate pubmed.ncbi.nlm.nih.gov/22001973/
Including--reduction in membrane fluidity due to decreased synthesis of membrane cholesterols, impaired mitochondrial function due to decreased synthesis of coenzyme Q, 
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This is a two part story (#RLR)
Each stands alone but their combination is multiplicative #Synergy #Interdependence
Today’s topic: “The sample is hemolyzed” - In vitro vs In vivo
This is a two part story (#RLR)
Each stands alone but their combination is multiplicative #Synergy #Interdependence
Today’s topic: “The sample is hemolyzed” - In vitro vs In vivo
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The lab notifies you “the sample is hemolyzed.”
First step in reasoning, did the hemolysis occur in the patient (in vivo) or during collection of the specimen (in vitro “ex vivo”), eg., prolonged application of tourniquet
The lab notifies you “the sample is hemolyzed.”
First step in reasoning, did the hemolysis occur in the patient (in vivo) or during collection of the specimen (in vitro “ex vivo”), eg., prolonged application of tourniquet
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In vivo hemolysis -> need to determine cause of hemolysis
In vitro hemolysis -> usually consequence of collection technique
In vivo hemolysis -> need to determine cause of hemolysis
In vitro hemolysis -> usually consequence of collection technique
1/
This is a two-part story (#RLR)
Each stands alone but their combination is multiplicative #Synergy #Interdependence
Today’s topic: “The sample is hemolyzed” - In vitro vs In vivo
This is a two-part story (#RLR)
Each stands alone but their combination is multiplicative #Synergy #Interdependence
Today’s topic: “The sample is hemolyzed” - In vitro vs In vivo
2/
The lab notifies you “the sample is hemolyzed.”
First step in reasoning, did the hemolysis occur in the patient (in vivo) or during collection of the specimen (in vitro “ex vivo”), eg., prolonged application of the tourniquet
The lab notifies you “the sample is hemolyzed.”
First step in reasoning, did the hemolysis occur in the patient (in vivo) or during collection of the specimen (in vitro “ex vivo”), eg., prolonged application of the tourniquet
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In vivo hemolysis -> need to determine the cause of hemolysis (part 2 by @rabihmgeha )
In vitro hemolysis -> usually consequence of collection technique
In vivo hemolysis -> need to determine the cause of hemolysis (part 2 by @rabihmgeha )
In vitro hemolysis -> usually consequence of collection technique
