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Análisis filogenético y de recombinación de virus similares al #SARSCoV2
La mayoría de los análisis se centra en RdRp como un gen conservado en una región que se cree que es menos propensa a la recombinación. Sin embargo, el análisis de identidad de nucleótidos y la filogenia ➡️
específica de genes revelan una recombinación desenfrenada entre los #SARSrCoV. La recombinación no solo puede dar como resultado una incongruencia filogenética, sino que también puede confundir las relaciones evolutivas cuando los eventos de recombinación ➡️
no se identifican fácilmente. En el caso de los virus similares al #SARSCoV2 como el #RmYN02 y #RacCS203, un árbol RdRp no sugiere una relación particularmente estrecha. Sin embargo, comparten un evento de recombinación de "S", lo que sugiere un ancestro común muy reciente. ➡️ Image
Read 6 tweets
Wow! My following went up literally by like 25% in one day. Please if you could all take a gander at my sticky, that would be great, whereby I am (AFAIK) the only person to do off-the-cuff math illustrating how bogus a 100% natural #furincleavagesite is in #SARSCoV2origins
threadreaderapp.com/thread/1339682…

and remember, the FCS itself is ectopic, and NO OTHER member of that sarbecovirus clade has one.

See Page 7: ncbi.nlm.nih.gov/corecgi/tilesh…
Additionally, as our ever-knowledgeable @Daoyu15 has repeatedly pointed out, all decent alignments of "FCS containing" coronaviruses that have been discovered after the pandemic such as #RmYN02 doesn't actually have an FCS...
Read 12 tweets

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