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High-order dynamics in brain networks & dementia are not well-captured by connectivity. We developed a new framework of high-order interactions (3-to-N plets) with information theory + greedy algorithm in #fMRI - #EEG across #AD & #FTD Paper doi.org/10.1016/j.nbd.… & 🧵👇1/5 
High-order functional connectivity (HOFC) at 3-15 plets yielded networks with large effect sizes for both modalities (fMRI and filtered EEG) and comparison (CN vs. AD, CN vs. FTD). Results included decorrelated networks for fMRI and EEG but also hyperconnectivity. 2/5
The fMRI/EEG characterization of neurodegeneration revealed hypo/hyperconnectivity on high-order interactions. Regions such as the amygdala, the insula, and the frontal gyrus were associated with both effects, suggesting more complex processes in hub regions. 3/5
