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More tweetorial! Let’s dig into the “proximity bias” we found @RecursionPharma confounding #CRISPR screens, what it means, and where it comes from.
You can always read along in the preprint here: biorxiv.org/content/10.110…
You can always read along in the preprint here: biorxiv.org/content/10.110…
If you missed the first tweetorial in the series, click here to understand what the red-and-blue heatmaps here mean, and how we use them to map the functions of genes at a genome-wide level:
To recap: if you knock out each gene in the genome, plot all their pairwise similarities, and sort by genomic position, a curious pattern emerges in which #CRISPR knockouts look more similar to KOs on the same chromosome arm than to KOs on other arms.
