Discover and read the best of Twitter Threads about #s31tb

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We are starting!

Are you ready? #CommunityConnect waits for you!
Tuit.cat/5ivrh
Dr. Payam Nahid explains the design of the trial:
#S31TB was a three-arm trial of:
2HPZE/2HP (4 months)
2HPZM/2HPM (4 months)
2HRZE/4HR (6 months) – control arm

It was open label, because with rifampicin is better to take without food whereas rifapentine is better with food🥑
Dorothy Namutamba answers about the collaboration communities- researchers.

One of community requests was to lower CD4 count limit to 100 for #PLWHIV to ensure we had enough data for this group.

Also, adolescents were included.

This ensures no delays in guidelines!
Read 19 tweets
About to start the session about the study that shows that High-dose rifapentine with moxifloxacin can shorten treatment time by a third for people with pulmonary #TB #UnionConf Image
📣 The #s31tb session starts!

#s31tb is the largest drug-sensitive #tb treatment trial in decades. It tested two arms vs. control aiming to shorten treatment to 4 months:
👉🏽substituting rifampicin with high-dose of rifapentine, &
👉🏽same + ethambutol for moxifloxacin ImageImage
🧫Innovation: the #S31TB enrolled 2,500 participants in 13 countries and included adolescents over 12, people living with HIV and people with cavitary #TB.

🤝Collaboration! #S31TB was an effort by two US-funded research networks: TBTC (at @CDC_TB) and @ACTGNetwork (at @NIH) Image
Read 10 tweets

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