Discover and read the best of Twitter Threads about #sarcomas
Most recents (2)
As promised, here is a #tweetorial on spatially-fractionated radiotherapy aka Lattice aka GRID.
If you missed the #CTOS2019 talk by @Notorious_RBE, this one is for you!
If you missed the #CTOS2019 talk by @Notorious_RBE, this one is for you!
Spatial fractionation aims to intentionally deliver heterogeneous dose: alternating “hot” and “cold” areas with a differential of 30-100% Rx.
Thats right: you want 30% cold spots in tumor. (👇 #MedPhys reaction).
Thats right: you want 30% cold spots in tumor. (👇 #MedPhys reaction).
It seems crazy, but it is associated with excellent response and limited toxicity. Per reports. That are retrospective.
Dramatic response in rads refractory sarcoma: link.springer.com/article/10.100…
Case series of 71 palliative patients: ncbi.nlm.nih.gov/pubmed/1052442…
Dramatic response in rads refractory sarcoma: link.springer.com/article/10.100…
Case series of 71 palliative patients: ncbi.nlm.nih.gov/pubmed/1052442…
1. My great thanks to @sandrapdangelo & @WTapMD for elaborating on the $250,000 grant they got from @CureSarcoma for uterine #leiomyosarcoma. curesarcoma.org/uterine-leiomy… Their research will help people with other #sarcoma subtypes, too. more ...
2. @sandrapdangelo says grant will go toward 2 immunotherapy #ClinicalTrials. She hopes the first will open @sloan_kettering in late spring. The first will combine a CSF-1R (DCC-3014 deciphera.com/pipeline/dcc-3…) with #avelumab (#Bavencio en.wikipedia.org/wiki/Avelumab). more ...
3. @sandrapdangelo doesn't know when the second #ClinicalTrial will open, but it will combine a PARP inhibitor (en.wikipedia.org/wiki/PARP_inhi…) an immunotherapy drug that has not been chosen yet. "Other #sarcoma subtypes will be allowed to enroll," not just #leiomyosarcoma. more ...
