Discover and read the best of Twitter Threads about #sarcomas

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As promised, here is a #tweetorial on spatially-fractionated radiotherapy aka Lattice aka GRID.

If you missed the #CTOS2019 talk by @Notorious_RBE, this one is for you!
Spatial fractionation aims to intentionally deliver heterogeneous dose: alternating “hot” and “cold” areas with a differential of 30-100% Rx.

Thats right: you want 30% cold spots in tumor. (👇 #MedPhys reaction).
It seems crazy, but it is associated with excellent response and limited toxicity. Per reports. That are retrospective.

Dramatic response in rads refractory sarcoma:…

Case series of 71 palliative patients:…
Read 14 tweets
1. My great thanks to @sandrapdangelo & @WTapMD for elaborating on the $250,000 grant they got from @CureSarcoma for uterine #leiomyosarcoma.… Their research will help people with other #sarcoma subtypes, too. more ...
2. @sandrapdangelo says grant will go toward 2 immunotherapy #ClinicalTrials. She hopes the first will open @sloan_kettering in late spring. The first will combine a CSF-1R (DCC-3014…) with #avelumab (#Bavencio more ...
3. @sandrapdangelo doesn't know when the second #ClinicalTrial will open, but it will combine a PARP inhibitor (…) an immunotherapy drug that has not been chosen yet. "Other #sarcoma subtypes will be allowed to enroll," not just #leiomyosarcoma. more ...
Read 11 tweets

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