Discover and read the best of Twitter Threads about #scTCRseq
Most recents (2)
Our immune system is essential in keeping us healthy.
But the immune system also changes profoundly as we age.
Why is that? Could we prevent it?
Let's see how #singlecell biology can help us better understand #immune #aging
🧵👇
But the immune system also changes profoundly as we age.
Why is that? Could we prevent it?
Let's see how #singlecell biology can help us better understand #immune #aging
🧵👇
First, some background.
Everybody knows that the immune system is hugely complex.
#singlecell sequencing has (arguably) done more for the immune system than for other health applications.
Via #scRNAseq, we discovered & characterized crazily detailed immune cell phenotypes.
Everybody knows that the immune system is hugely complex.
#singlecell sequencing has (arguably) done more for the immune system than for other health applications.
Via #scRNAseq, we discovered & characterized crazily detailed immune cell phenotypes.
Such detailed phenotypes have been found in both healthy and diseased tissues.
I wrote several threads about this topic and find it to be one of the most foundational & fascinating progresses that have happened in biomedicine in the past 10 years.
I wrote several threads about this topic and find it to be one of the most foundational & fascinating progresses that have happened in biomedicine in the past 10 years.
Today's amazing science dives deep into the 2 strongest #cancer modulators: evolution & immune defense.
First-ever detailed temporal evolutionary trajectories for 600,000 B cell lymphoma immune cells #scRNAseq & #scTCRSeq of 32 patients during immunotherapy with 2 CAR-T drugs 🧵
First-ever detailed temporal evolutionary trajectories for 600,000 B cell lymphoma immune cells #scRNAseq & #scTCRSeq of 32 patients during immunotherapy with 2 CAR-T drugs 🧵
First, what is chimeric antigen receptor (CAR) T cell therapy?
It is an immunotherapy in which the patient's own immune cells are genetically engineered ex-vivo to recognize, attack & kill tumor cells. Then they are infused back into the patient, ready to fight the enemy!🤺 2/13
It is an immunotherapy in which the patient's own immune cells are genetically engineered ex-vivo to recognize, attack & kill tumor cells. Then they are infused back into the patient, ready to fight the enemy!🤺 2/13
Immunotherapies have revolutionized cancer treatment & are among the most promising future approaches.
However: response rates, even if varying across cancers, remain limited, with e.g. 50% response in lymphomas.
Why such therapies fail for the other half remains a mystery 3/13
However: response rates, even if varying across cancers, remain limited, with e.g. 50% response in lymphomas.
Why such therapies fail for the other half remains a mystery 3/13
