Discover and read the best of Twitter Threads about #serology

Most recents (3)

1/ Q: I see advertisements for #COVID antibody tests. Is it worth getting tested? What will an antibody test tell me?

A: Your antibody test results may not be as useful on a personal level just yet. HOWEVER, they help us understand #Covid and its spread through a population!
2/ When considering a #serology test, we encourage you to think about WHY you are getting the test, WHERE you will receive the test, and how it will influence knowledge about #Covid_19 at large.

More on these points below:
3/ WHY: Antibody tests detect if the #ImmuneSystem responded to a particular virus after exposure.
Population-level antibody tests generate data on the number of people who were exposed and responded to a virus. They help us track the true ”footprint” of the virus to date. 👣
Read 9 tweets
Thoughts on upcoming #COVID19 #serology tests:
This is actually quite a challenge! (#Diagnostics often involve a lot of complexities). There is a lot of pressure to roll these tests out, but they need to perform well, or we do more harm than good. #MicroRounds (A thread)
WHY we need these soon:
1. Contact tracing.
2. Can be used to test if a vaccine is working during a clinical trial (70 of them ongoing right now, I believe)
3. Inform public policy makers about rate of asymptomatic cases + previous infections/exposures =informed decision making
How is developing a #PCR different than developing a #serology test?
1. #PCR tests detect viral RNA/DNA (in this case RNA) and can be pretty straight-forward in terms of development
2. #Serology relies on knowing about the #SARSCoV2 structure and how the human body responds.
Read 13 tweets
I want to separately pull out this graphic from the @ASMicrobiology #COVID19 #testing paper since I think it’s *super* helpful. #RNA tests tell us if you’re infected right now (mostly, see next tweet). #Serology tells us if you were recently(ish) infected.
1st important point. RNA tests can pick up any viral RNA, whether that’s live infectious virus or garbage RNA still in your body. Also the sample might not capture RNA (say the virus is in your GI not your nose & we sample your nose). This can give false negatives.
2nd point. Serology doesn’t typically make for good rapid tests, since your body needs time to make antibodies. You don’t magically make them as soon as you see a pathogen, it takes a few days for the machinery to get warmed up and going (think like a factory).
Read 5 tweets

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