Discover and read the best of Twitter Threads about #shiftwork

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[1/10]

A thread on our new piece in @FASEBorg

β€œCircadian misalignment disturbs the skeletal muscle lipidome in healthy young men” #shiftwork

@rhhoutkooper @SchrauwenP

dx.doi.org/10.1096/fj.202…
2/10

Circadian misalignment, as seen in night-shift work, is associated with a ‴️ risk to develop many different pathologies (see figure below), especially #obesity and type 2 #diabetes are quite common in shift-workers.

tinyurl.com/w2j7kes3
3/10

Our group @DMRG_UM recently showed that simulating #shiftwork for 3 nights leads to:

➑️ disruption of the core molecular clock
➑️ induction of enhanced lipid metabolism pathways
➑️ insulin resistance in skeletal muscle of young healthy πŸ‘¨

pnas.org/content/115/30…
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