Discover and read the best of Twitter Threads about #sid2021
Most recents (8)
First State of the Art Lecture on Thursday was Isaac Brownell from the Dermatology Branch at @NIH_NIAMS, in a talk titled "Merkel cells and Merkel cell carcinoma: neuroendocrine skin cells from development to cancer" 1/n #sid2021
Merkel cells are innervated neuroendocrine cells, and they function as mechanical sensors. In mouse skin they actually cluster around specialized keratinocytes that are part of structure call the 'touch dome'
2/n #sid 2021
2/n #sid 2021
It turns out that sonic hedgehog signaling from sensory nerves is required to maintain that touch dome - this is a deep connection between the nervous system and keratinocytes
3/n #sid2021
3/n #sid2021
Last talk of Plenary III comes from @KYTsaiLab, titled "Topical MEK Inhibition as Precision Targeted Chemoprevention". Like the 1st talk by @CarolynLeeMDPhD, this talk is focused on cutaneous squamous cell carcinoma 1/n #SID2021
In prior work (nature.com/articles/ncomm…) this group found that MEK inhibition could help prevent progression of lesions from premalignant actinic keratosis to cutaneous SCC #sid2021 2/n
They use a hairless mouse UV-driven cutaneous SCC model for preclinical testing, and found that systemic MEK inhibition prevented skin cancer lesions. To avoid systemic side effects thought, they developed a topical MEK inhibitor gel #sid2021 3/n
Talk #3 in Plenary III - "Involucrin Deficiency results in Decreased Vitamin D Receptor‐Mediated Inflammation and Csnk1e Isoform Bias" from the lab of @cdgstrong21 at @WashUDerm #sid2021 1/n
Involucrin is a major scaffolding protein in the epidermis, and the @cdgstrong21 lab recently discovered that there is a positive selection pressure for increased involucrin expression out-of-Africa - this is work that is in press @sid2021 2/n
Interesting that involucrin knockout mice develop a normal skin barrier - but the role of involucrin for skin homeostasis is not known. To determine the response, a well known vitD agonist model of cutaneous inflammation was applied to involucrin knockout mice #sid2021 3/n
Talk #2 from Plenary III is from @NUFeinbergDerm, José-Marc Techner, presenting "Oral Vitamin D3 reduces chemical-induced skin inflammation in humans" #SID2021 1/n
The focus of this work is to understand the mechanisms of chemical-induced skin inflammation, and to unravel how systemic vitamin D3 can suppress the deep dermal inflammatory response. @SID2021 2/n
The investigators designed a double blinded RCT - 28 healthy volunteers had 2 exposures to topical nitrogen mustard, half got vitamin D3 and half got placebo at the 2nd nitrogen mustard exposure, and labs, skin biopsy, and skin redness was measured throughout 3/n #sid2021
In Plenary III, @CarolynLeeMDPhD starts off with "Somatic Mutation of the OXA1L 5’UTR enables Cutaneous Squamous Cell Carcinoma". Skin cancer is the most common malignancy, and rates of SCC may be similar to BCC, 100k SCC metastasize annually with limited tx options. #SID2021 1/
Surgery is standard of care for SCC, but for many patients surgery is not an option and Dr. Lee sought to determine actionable genetic alterations in SCC to inspire targeted non-surgical treatment options #SID2021 2/n
In previous work, Dr. Lee and colleagues performed sequencing of SCC (pubmed.ncbi.nlm.nih.gov/25194279/) and did not find clear tumor driving mutations #SID2021 3/n
"Epidemiology and risk factors for the development of cutaneous toxicities in patients treated with immune checkpoint inhibitors: A United States population-level analysis" by @EugeneSemenovMD
Immune checkpoint inhibitors have improved survival across multiple cancers. However, they can cause cutaneous immune-related adverse events (irAEs). >40 cutaneous eruptions have been associated with ICIs, including immunobullous, lichenoid dermatitis, & psoriasiform. #SID2021
They performed an observational study comparing patients on ICIs to matched controls. They found the overall incidence of immune-related adverse events to be 25% in the real world, lower than estimates in clinical trials. #SID2021
Excited to tune into the @FLOWJamaica Foundation's Safer Internet Day Teen Summit! Happening now. 🤗🤗🤗
How many internet providers acknowledge their duty in recognizing & addressing online safety!? Already off to a great start @FLOWJamaica
Just about everything is online now! Addressing safety, especially among young people, is a must!
#SID2021 #InnaRealLife #SafeYouth
Just about everything is online now! Addressing safety, especially among young people, is a must!
#SID2021 #InnaRealLife #SafeYouth
Everyone has a responsibility to make a positive difference online! Parents, Government, Students, Seniors, All of us!
#SID2021 #SaferInternetDay #InnaRealLife
#SID2021 #SaferInternetDay #InnaRealLife
Today we call upon policy makers to work towards facilitating a better, safer & affordable internet for our children and youth, by creating strategies and legal & regulatory frameworks
@presidencymv @mvpeoplesmajlis @MoCSTmv @PoIiceMv @MohamedNasheed @ibusolih
#SaferInternetDay
@presidencymv @mvpeoplesmajlis @MoCSTmv @PoIiceMv @MohamedNasheed @ibusolih
#SaferInternetDay
It is important to base these on continuous dialogue and consultation with young minds and relevant stakeholders, with better focus on outcomes that are relevant to the realities of today.
These are necessary for them to engage as global digital citizens, to bring out their creative and entrepreneurial selves to the fullest, while safeguarding their rights.
#SaferInternetDay #SID2021
#SaferInternetDay #SID2021
