Discover and read the best of Twitter Threads about #sidu
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2. Python code 
1. mpox: human monkeypox virus (hMPXV) doesn't enter the nucleus. Genetic recombination with SARS-CoV-2 in the cytoplasm is possible in co-infected patients, eg people living with uncontrolled HIV-1 (PLH). It's the real threat of Covid Denial or Let 'er RIP policy.
#SIDU 230206
#SIDU 230206
2. Covid can have the same effect, causing lymphopenia in perhaps 1 in 3 patients (severe #LongCOVID (#LongSARS) can be compared to HIV/AIDS).
Influenza, SARS, HIV, mpox Protein E8L follow shared evolutionary dynamics for electrostatic surface potential & co-receptor switching.
Influenza, SARS, HIV, mpox Protein E8L follow shared evolutionary dynamics for electrostatic surface potential & co-receptor switching.
3. Practical implication for clinicians: Test patients presenting with mpox symptoms for all three diseases.
Practical implications for all else: read science.
sciencedirect.com/science/articl…
mdpi.com/1999-4915/15/2…
mdpi.com/1420-3049/27/1…
mdpi.com/1999-4915/14/1…
Practical implications for all else: read science.
sciencedirect.com/science/articl…
mdpi.com/1999-4915/15/2…
mdpi.com/1420-3049/27/1…
mdpi.com/1999-4915/14/1…
1. Congrats us, SARS-CoV-2 mutational fitness is steadily increasing thanks to unmitigated pandemic spread. Genuinely impressive to watch evolution happening live!
#SIDU 230205
#SIDU 230205
2. Direct link: For XAY.2 and XBF, click on the enlarged grey dots on the right (dis/activate search function on top or add your own). nextstrain.org/groups/neherla…
3. Stone Reality Check Mark if you can explain the emerging wave pattern. What we were sold as endemic is no sustainable quasi-equilibrium state.
In reality, we will see three overlapping co-circulating waves every three months, each separated by a month.
In reality, we will see three overlapping co-circulating waves every three months, each separated by a month.
1. What is our problem?
Pandemic policy is lost because no one puts the key message in one text / tweet, so it’s ALWAYS lost in translation. People switch off halfway through
One sense unit: (1) SARS risk; (2) what’s missing or to be done; (3) concrete group or demand to do it.
Pandemic policy is lost because no one puts the key message in one text / tweet, so it’s ALWAYS lost in translation. People switch off halfway through
One sense unit: (1) SARS risk; (2) what’s missing or to be done; (3) concrete group or demand to do it.
2. Okay journalists, let’s practice.
Guess why I like this article so much? Hint, read the headline
Guess why I like this article so much? Hint, read the headline
3. Correct. (1) Do the thing where you don’t just copy-paste the words of power. (2) We have a problem of missing, cooked or ill understood data worldwide. It’s fast getting worse. (3) Talk to *former* or independent (=unscripted) public health experts.
Some are even on Twitter!
Some are even on Twitter!
1. What role for aerosols in climate change and SARS/respiratory ID transmission?
“That your gas stove can cause more exposure than a nearby highway is counterintuitive. But intuition is wrong. Measurements, models, principles of air pollution dispersion are right.” #SIDU 230114
“That your gas stove can cause more exposure than a nearby highway is counterintuitive. But intuition is wrong. Measurements, models, principles of air pollution dispersion are right.” #SIDU 230114
2. Interesting exchange with @jembendell, with whom I see eye to eye on climate (Hansen’s Faustian aerosol bargain), even if not yet on SARS.
Aerosols transport virions in airborne droplets that move like smoke.
Aerosols transport virions in airborne droplets that move like smoke.
3. To mount an infection, virions landing in your mouth or eyes need to outnumber antibodies. Each droplet carries around 700 virions; if you have some 1000 antibodies in place, you need 1000 virions.
This is what made Omicron so dangerous: 1-2 droplets - a breath - can suffice.
This is what made Omicron so dangerous: 1-2 droplets - a breath - can suffice.
1. Shall I continue the #SIDU format in 2023?
"Syndemic infectious disease update 230109, incl. politics of #sars #mpox #climate"
We learned the wrong lessons from pandemic errors in China and the west but I can't fill holes in public policy. Some of you/us need to learn fast.
"Syndemic infectious disease update 230109, incl. politics of #sars #mpox #climate"
We learned the wrong lessons from pandemic errors in China and the west but I can't fill holes in public policy. Some of you/us need to learn fast.
2. Here another outstanding thread by @RealCheckMarker that's sure to fly under the radar.
@RealCheckMarker 3. As shared previously. Hundreds of millions will suffer from Long SARS. We not only waste the ongoing population-level experiment - because states don't collect data, despite their legal obligations under IHR 2005 - but even threw away data that existed.
(1) How will states stop SARS?
We covered the problem; let's explain the solution next year to help people
These elements sustain the pandemic:
(a) Airborne transmission
(b) Immunodeficiency
(c) Lack of leadership
Walensky speaks the truth. CDC can't control (c). #SIDU 221231
We covered the problem; let's explain the solution next year to help people
These elements sustain the pandemic:
(a) Airborne transmission
(b) Immunodeficiency
(c) Lack of leadership
Walensky speaks the truth. CDC can't control (c). #SIDU 221231
(a) airborne spread is known and we have solutions: Check ✅
(b) immunodeficiency/#LeonardiEffect are deniable. Read @RealCheckMarker @fitterhappierAJ
It's dynamic: no solutions but (a) will work. Check ✅
(c) Unaccountable leadership is the problem. ⛔️
(b) immunodeficiency/#LeonardiEffect are deniable. Read @RealCheckMarker @fitterhappierAJ
It's dynamic: no solutions but (a) will work. Check ✅
(c) Unaccountable leadership is the problem. ⛔️
@RealCheckMarker @fitterhappierAJ (3) Now reframe the question
How can states stop (a) airborne spread and (b) individual and population-level immunodeficiency to end the pandemic with the tools available (WHO IHR 2005)?
What is the alternative (BATNA) if they don't?
Here the solution:
How can states stop (a) airborne spread and (b) individual and population-level immunodeficiency to end the pandemic with the tools available (WHO IHR 2005)?
What is the alternative (BATNA) if they don't?
Here the solution:
1. How does SARS cause AIDS?
The virus SARS-CoV causes systemic chronic immune activation, loss of plasmacytoid dendritic cells (pDC), naive T and B cells, and acquired immunodeficiency syndrome (AIDS)
I would propose the name airborne immunodeficiency virus (#AIV) #SIDU 221225
The virus SARS-CoV causes systemic chronic immune activation, loss of plasmacytoid dendritic cells (pDC), naive T and B cells, and acquired immunodeficiency syndrome (AIDS)
I would propose the name airborne immunodeficiency virus (#AIV) #SIDU 221225
2. COVID19 (SARS) is transient because the virus clears as epithelial cells regenerate. It extends the infected cell's life (500-787 days in the renal epithelium). It causes #AirborneAIDS in SARS survivors; hence the need for #ZEROairborneAIDS (#ZeroCOVID)
3. Immune damage acquired from SARS (Covid) can be premanent
What causes SARS-associated chronic immune activation? - @fitterhappierAJ published early and warned the public most consistently. We all owe him
frontiersin.org/articles/10.33…
mdpi.com/2076-0817/11/4…
frontiersin.org/articles/10.33…
What causes SARS-associated chronic immune activation? - @fitterhappierAJ published early and warned the public most consistently. We all owe him
frontiersin.org/articles/10.33…
mdpi.com/2076-0817/11/4…
frontiersin.org/articles/10.33…
#RealityCheck: Counter to naïve, disempowering stories, we CAN end SARS-CoV-2 just like SARS. The virus isn't novel. It worked so well in 2003, most never noticed that international travel surveillance is key.
Follow the Precautionary Principle: N95 grade PPE and eye protection.
Follow the Precautionary Principle: N95 grade PPE and eye protection.
End the SARS pandemic fast to be able to mitigate climate breakdown. Maybe this can help:
Once you sort out SARS, go back to climate. Promise, it won’t be boring. There is no logical or ethical alternative.
