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1/ Meanwhile, back in the Land of Lipids...
If I seem a lot less active lately, it's because I'm prepping for something big next week. I'll tell you all about it in 7 days ;)
However, there are also two lipid-related things that have been underway that I'm very exited about..
If I seem a lot less active lately, it's because I'm prepping for something big next week. I'll tell you all about it in 7 days ;)
However, there are also two lipid-related things that have been underway that I'm very exited about..
2/ One is that I've been having a very exhaustive conversation with @NutritionDanny and Alan Flanagan of #SigmaNutritionRadio via email the last several days regarding the #LipidTriad and I think it's be very productive and respectful...
3/ Two, a while ago I tasked @siobhan_huggins with doing a review on studies for #Cholesterol/#Lipoproteins and #Viruses. As usual she's knocked it out of the park. Should be launching early next week on CholesterolCode.com, of course.
1/ Live Read Through Thread
1st... a setup:
A while ago I guested on @NutritionDanny's podcast #SigmaNutritionRadio. Alan Flanagan and I discussed #Lipids, #LDL #Cholesterol, #Atherosclerosis, etc. If you haven't already listened, I highly recommend it sigmanutrition.com/episode321/
1st... a setup:
A while ago I guested on @NutritionDanny's podcast #SigmaNutritionRadio. Alan Flanagan and I discussed #Lipids, #LDL #Cholesterol, #Atherosclerosis, etc. If you haven't already listened, I highly recommend it sigmanutrition.com/episode321/
2/ Today @NutritionDanny let me know they have an article out rebutting my points found here: sigmanutrition.com/lipid-triad/
As always, I encourage you to read their article with an open mind. Then feel free to come back here for my first impressions.
Let's get started...
As always, I encourage you to read their article with an open mind. Then feel free to come back here for my first impressions.
Let's get started...
3/ Oh -- the beginning of the article includes a tweet from a #ListenThread I did when the podcast was dropped. That can be found here:
1/ Thread — Does the Lipid Hypothesis account for a slow down in advanced age?
Alan Flanagan makes an interesting point at around 51:20 in our podcast for #SigmaNutritionRadio. Please listen to get full context.
sigmanutrition.com/episode321/
Alan Flanagan makes an interesting point at around 51:20 in our podcast for #SigmaNutritionRadio. Please listen to get full context.
sigmanutrition.com/episode321/
2/ In short (and correct me, Alan or @NutritionDanny, if I’m not representing it correctly):
Interventions with lowering LDL when at an advanced age have much less effect because of the previous cumulative burden of LDL.
As Alan put it, it’s “too little, too late.”...
Interventions with lowering LDL when at an advanced age have much less effect because of the previous cumulative burden of LDL.
As Alan put it, it’s “too little, too late.”...
3/ I’d argue it should be exactly the reverse if we follow the logic of the Lipid Hypothesis and what cumulative burden represents.
The scale should be:
Low athero = less chance of benefit in intervention
...
High athero = more chance of benefit in intervention
The scale should be:
Low athero = less chance of benefit in intervention
...
High athero = more chance of benefit in intervention
1/ #ListenThread -
My guest appearance on #SigmaNutritionRadio just dropped where I have a very friendly #debate with @NutritionDanny and Alan Flanagan on #LDL #Cholesterol, #ApoB, #Atherosclerosis, #AllCauseMortality & much, much more!
sigmanutrition.com/episode321/
My guest appearance on #SigmaNutritionRadio just dropped where I have a very friendly #debate with @NutritionDanny and Alan Flanagan on #LDL #Cholesterol, #ApoB, #Atherosclerosis, #AllCauseMortality & much, much more!
sigmanutrition.com/episode321/
2/ I did this podcast semi-sleep deprived and between interviews for #TheCCDoc. But I know my main hopes going in were to emphasize:
(1) Why I favor the "Lipid profile-centric" model over the "Lipoprotein-centric" model.
(2) How this is relevant to "the triad" ⬆️LDL⬆️HDL⬇️TG
(1) Why I favor the "Lipid profile-centric" model over the "Lipoprotein-centric" model.
(2) How this is relevant to "the triad" ⬆️LDL⬆️HDL⬇️TG
3/
(3) Why this triad is of particular interest to all of us as it relates to not just cardiovascular disease, but in particular -- all cause mortality (ACM)
I honestly couldn't remember how well I did in getting these core points across, thus relistening now...
(3) Why this triad is of particular interest to all of us as it relates to not just cardiovascular disease, but in particular -- all cause mortality (ACM)
I honestly couldn't remember how well I did in getting these core points across, thus relistening now...
