Discover and read the best of Twitter Threads about #singlecellSkeptics
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Did you know #lipids control cell identity? Yes, they do! Happy to share our first preprint on #singlecell #lipidomics in collaboration with @gio_dangelo and a fabulous team led by @CapolupoLaura and Irina Khven. biorxiv.org/content/10.110… 
We used #MALDI imaging mass spectrometry to measure the single-cell lipidomes of hundreds of individual human dermal #fibroblasts. We identify specific lipid metabolic pathways that display cell-to-cell variability. Unexpectedly, single cells clustered by lipid composition!
It took a lot of experiments to convince us, but now we can say it confidently: there is such a thing as a #lipotype!! First of all, toxin-based lipid staining validated the existence of the different populations of dermal fibroblasts both in vitro and in vivo.
