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New @medrxivpreprint from work over 5 years with @tsanglab!
Our framework for integrating human population & single cell variations identified a "naturally adjuvanted" baseline immune system setpoint linked to more robust & immunogenic vaccine responses.
medrxiv.org/content/10.110…
Our framework for integrating human population & single cell variations identified a "naturally adjuvanted" baseline immune system setpoint linked to more robust & immunogenic vaccine responses.
medrxiv.org/content/10.110…
We used mixed effects models to decompose variation in every gene attributable to cell type (defined by surface protein), individual, age, sex, and vaccination effects. Individual differences often explain substantial variation, highlighting the need for hierarchical models. 
After accounting for human population variation, we defined vaccine-induced transcriptome perturbations in each cell type, then integrated these statistical model results with "bottom up" computational reconstructions of transcriptional dynamics.
