Discover and read the best of Twitter Threads about #slc6a19
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(1/8) #ACE2, which also likely coats the virus and hijacks the B(0)AT1 / #SLC6A19 amino acid transporter pathway, is the viral entry mechanism for #SARSCoV2. ACE2 is a co-receptor with SLC6A19. Hartnup disease (en.wikipedia.org/wiki/Hartnup_dā¦) is characterized by mutations in #SLC6A19. 
(2/8) If #SARSCoV2 #COVID #coronavirus is interfering with the ACE2-B(0)AT1 complex (see structural data below and at biorxiv.org/content/10.110ā¦), and/or collectrin (which shares significant homology with ACE2 and is an unexplored potential mechanism of entry for SARS as well)...
(3/8) ...it is mechanistically likely that we will see many symptoms of #COVID19 / #COVID / #CORONAVIRUS / #SARSCoV2 that overlap with Hartnup disease.
"Excessive amounts of amino acids, such as tryptophan, are excreted in the urine."
"Excessive amounts of amino acids, such as tryptophan, are excreted in the urine."
