Discover and read the best of Twitter Threads about #slc6a19

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(1/8) #ACE2, which also likely coats the virus and hijacks the B(0)AT1 / #SLC6A19 amino acid transporter pathway, is the viral entry mechanism for #SARSCoV2. ACE2 is a co-receptor with SLC6A19. Hartnup disease (en.wikipedia.org/wiki/Hartnup_dā€¦) is characterized by mutations in #SLC6A19.
(2/8) If #SARSCoV2 #COVID #coronavirus is interfering with the ACE2-B(0)AT1 complex (see structural data below and at biorxiv.org/content/10.110ā€¦), and/or collectrin (which shares significant homology with ACE2 and is an unexplored potential mechanism of entry for SARS as well)...
(3/8) ...it is mechanistically likely that we will see many symptoms of #COVID19 / #COVID / #CORONAVIRUS / #SARSCoV2 that overlap with Hartnup disease.

"Excessive amounts of amino acids, such as tryptophan, are excreted in the urine."
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