Discover and read the best of Twitter Threads about #sle
Most recents (19)
@JeremyVineOn5 I worked from the age of 16 I was struck down with Fibromyalgia when I was 29 this was a few years after I was attacked at work with a knife, the attacked in the street by a gang because the Met released my name in court.
I found myself sick and bedbound, I got back on my feet
I found myself sick and bedbound, I got back on my feet
@JeremyVineOn5 Many times, the illness come back and knocked me back down, I am 42 I was was also misdiagnosed with coeliac disease 2013 in 2022 I was diagnosed with #SLE my life will never be normal.
I have pain every day to the point I wish I was dead I miss outings with my children.
I have pain every day to the point I wish I was dead I miss outings with my children.
@JeremyVineOn5 @JeremyVineOn5 Maybe we should swap lives and come and live a few days in my shoes, I miss walks in the forest, I have had 3 days of pain and not much sleep. I have doctors that say your fat thats why your ill, I been ill from 69Kg the limits I face some days.
Embarazo en Lupus
Dr. Guillermo Ruiz Irastorza
#SLE #pregnancy🧵🩻🫁🫀🤰
#25TenTopicsBCN #TenTopics
Esencial la visita preconcepcional (y su checklist)
Dr. Guillermo Ruiz Irastorza
#SLE #pregnancy🧵🩻🫁🫀🤰
#25TenTopicsBCN #TenTopics
Esencial la visita preconcepcional (y su checklist)
Perfil de anticuerpos #antifosfolípido en pacientes con #lupus eritematoso sistémico
Dra. Leyre Riancho Zarrabeita
#APS #aPL #SLE #LA #aCL #aB2GP1 #aPS #PT🩸
#25TenTopicsBCN #TenTopics
Dra. Leyre Riancho Zarrabeita
#APS #aPL #SLE #LA #aCL #aB2GP1 #aPS #PT🩸
#25TenTopicsBCN #TenTopics
¿Podemos cambiar el curso de la enfermedad en pacientes con #lupus?
🫘🧪💉💊🏥⚕️🩻🫀🫁🔬🥼🩺
Dra. María José Cuadrado
#SLE #disease #modifying #therapy
#damageaccrual #SDI #SLEDAI #reducetoxicity
#25TenTopicsBCN
🫘🧪💉💊🏥⚕️🩻🫀🫁🔬🥼🩺
Dra. María José Cuadrado
#SLE #disease #modifying #therapy
#damageaccrual #SDI #SLEDAI #reducetoxicity
#25TenTopicsBCN
Baja actividad y remisión en #lupus #EULAR
#LLDAS & #DORIS
#SLE #disease #modifying #therapy
#damageaccrual #SDI #SLEDAI #reducetoxicity
#25TenTopicsBCN
#LLDAS & #DORIS
#SLE #disease #modifying #therapy
#damageaccrual #SDI #SLEDAI #reducetoxicity
#25TenTopicsBCN
Curso de la enfermedad en #lupus
#SLE #disease #modifying #therapy
#damageaccrual #SDI #SLEDAI #reducetoxicity
#25TenTopicsBCN
#SLE #disease #modifying #therapy
#damageaccrual #SDI #SLEDAI #reducetoxicity
#25TenTopicsBCN
3⃣Attribution #NPSLE
Thrilled to share our latest article in @NaturePortfolio Reviews Immunology exploring the role of platelets in #immune mediated inflammatory diseases such as #SLE. Open access link 🔓 rdcu.be/c4ijW.
A thread
A thread
In autoimmune & inflammatory diseases, platelets get activated in response to circulating autoAbs (directly or through FcGR2A binding), soluble factors such as DAMPs or infectious agents (ie through platelet TLR7). Platelet activation often follows disease activity -> biomarker
Upon activation platelets release pro-inflammatory molecules (ie, IL1b), express glycoproteins that promote the interaction with immune cells (ie P-selectin or CD40L) and release plat-derived extracellular vesicles which enhance the inflam « signal » thorough body & organs.
Back in the days of John Humphrey Noyes before he got suspended for posting a study indicating there's viral persistence in epithelium of kids, because everyone includes kids.
How does a twit like this get 108K views propagating “what if viral persistence is REAL”?
It’s almost like we are back to banning twitter accounts for insisting SARS is airborne!
It’s almost like we are back to banning twitter accounts for insisting SARS is airborne!
WHEN the rest of non-SARS experts acknowledge that “viral persistence is a thing”, we will be one step closer to acknowledging the true immunity dysfunction threat of SARS
#AirborneAIDS
#AirborneAIDS
🧵 Short summary thread on our recent publication looking at the impact of Anti-Rituximab Antibodies in #SLE with our recent manuscript published in @RheumJnl
This has been a story that we have been looking at for a few years now
💻 Link - academic.oup.com/rheumatology/a…
This has been a story that we have been looking at for a few years now
💻 Link - academic.oup.com/rheumatology/a…
In spite of failing to meet primary endpoints in the LUNAR and EXPLORER trials, a number of Open Label studies have shown benefit of B cell depletion with Rituximab in #lupus
In England, we have access to the drug for severe and refractory cases 💊 💉
england.nhs.uk/wp-content/upl…
In England, we have access to the drug for severe and refractory cases 💊 💉
england.nhs.uk/wp-content/upl…
During my time at @uclmedsci I was interested as to why patients receiving rituximab for #SLE occasionally developed infusion reactions to treatment, whilst I did not see this in patients receiving the drug for rheumatoid arthritis 🤔
1⃣GLORIA pragmatic trial in RA >= 65 yrs, of add on low dose prednisolone
pubmed.ncbi.nlm.nih.gov/35641125/
NNH 9.5
#ACR22
pubmed.ncbi.nlm.nih.gov/35641125/
NNH 9.5
#ACR22
How to weigh benefits and harms in GLORIA?
👉The protocol of this study provides tips to interpret the findings
#ACR22
👉The protocol of this study provides tips to interpret the findings
#ACR22
É DAQUI A POUCO! A GRANDE ABERTURA DOS JOGOS OLÍMPICOS DE VERÃO TÓQUIO 2020!
A partir das 08h, ao vivo na Globo, SporTV e BandSports!
#Tokyo2020 #JogosOlímpicos
A partir das 08h, ao vivo na Globo, SporTV e BandSports!
#Tokyo2020 #JogosOlímpicos
20 MINUTOS! Bruno e Ketleyn já estão no preparo!
📸 Christian Dawes/COB
📸 Christian Dawes/COB
COMEÇOU! FINALMENTE 😭😭😭😭😭
Did you miss the talk "Panorama of #lupus in 2020?" I did yesterday for @LupusEurope?
No worries, I'm starting a #tweeter #SLE #thread so that you can pick up the slides you're interested in 👍
Check below for the SLIDES ⬇️
No worries, I'm starting a #tweeter #SLE #thread so that you can pick up the slides you're interested in 👍
Check below for the SLIDES ⬇️
Good Morning #MedTwitter #neurotwitter #MedEd #Neurotwt #Neuroresidents #NeuroOphthalmology #Neuroimmunology #twittorial. Let's have a quick review on #OpticNeuritis and #NMO - Grab a #coffee and let's Start!
1/ Classic #opticneuritis is characterized by a sub-acute loss of vision in one Eye, with central #scotoma, pain on #eyemovement, positive #RAPD
- Fundus exam is usually normal
- Age range 15-45 years
- Fundus exam is usually normal
- Age range 15-45 years
2/Talking about #MOGAntibodies:
- More frequent in #pediatric population, Associated with #ADEM
- #MOG IgG serum titers depend on disease activity and is mainly from extrathecal origin, enters #CNS from systemic circulation and reaches CSF through passive diffusion or broken #BBB
- More frequent in #pediatric population, Associated with #ADEM
- #MOG IgG serum titers depend on disease activity and is mainly from extrathecal origin, enters #CNS from systemic circulation and reaches CSF through passive diffusion or broken #BBB
Time again for #NeuromuscularQandA? RT. #neurology #medtwitter #MedEd #medstudent #neurologyresident Join me in discussing/learning/educating with #passion and #humor @WNGtweets @MedTweetorials @MadSattinJ @NinaRiggins @AaronLBerkowitz @Tracey1milligan
Q. What up doc. My #IBM patient doesn’t have #NT51a antibodies and my #SLE patient has #NT51a antibodies. I’m confused.
A: If only life wasn’t messy. 30 percent of #IBM patients don’t have #NT51a and false positives happen with #SLE and #Sjogrens which can cause #overlapmyositis.
@ClareWHarris @DemocracyStorm @meg_Y12 @WisePaxCat @KikiAdine @jomareewade @jacknielsenN7 @Trumpet1984 @morethanmySLE @brycetache @axidentaliberal @ShuriResists @horridpoplyrics @ScarletAvengers @TheSWPrincess @TeelaResists @bannerite @MplsMe @MsActiviss Day: #2 bc I had to break quarantine to venture out in search of the elusive creature known as "Toilet Paper"- alas, I was unsuccessful but I did buy a tidy amount of Kleenex which shall do doubt duty." 😷 😂✌
@ClareWHarris @DemocracyStorm @meg_Y12 @WisePaxCat @KikiAdine @jomareewade @jacknielsenN7 @Trumpet1984 @morethanmySLE @brycetache @axidentaliberal @ShuriResists @horridpoplyrics @ScarletAvengers @TheSWPrincess @TeelaResists @bannerite @MplsMe @MsActiviss "Double" d*mn you spell check! 😱
@ClareWHarris @DemocracyStorm @meg_Y12 @WisePaxCat @KikiAdine @jomareewade @jacknielsenN7 @Trumpet1984 @morethanmySLE @brycetache @axidentaliberal @ShuriResists @horridpoplyrics @ScarletAvengers @TheSWPrincess @TeelaResists @bannerite @MplsMe @MsActiviss @Planetscape
@ToBeSafeNSound
@tazarae20
@chicating
@etta8247 (yes she's real & a great follow!)
@pr0udsnowflake
@YvetteJacqR
@cat_persists
@Sophia_RESISTS @Ruatha_Pern
@RavenRlyyeh
@joeynova33
@PDKMom
@tis_me_ingrid
@DutchResister
@JimmyStreich
@model_daughters
@ToBeSafeNSound
@tazarae20
@chicating
@etta8247 (yes she's real & a great follow!)
@pr0udsnowflake
@YvetteJacqR
@cat_persists
@Sophia_RESISTS @Ruatha_Pern
@RavenRlyyeh
@joeynova33
@PDKMom
@tis_me_ingrid
@DutchResister
@JimmyStreich
@model_daughters
1/
Hi hi hi. We see lots of red flags on a daily basis when we review labs.
One thing we see commonly is #lymphopenia. Should we care? When can we dismiss it and when should we work it up?
Let’s find out.
#MedEd #MedTwitter #IDTwitter #Tweetorial #oncology
Hi hi hi. We see lots of red flags on a daily basis when we review labs.
One thing we see commonly is #lymphopenia. Should we care? When can we dismiss it and when should we work it up?
Let’s find out.
#MedEd #MedTwitter #IDTwitter #Tweetorial #oncology
2/
- Lymphopenia assc w/ ⬆️risk of sepsis
- More common in elderly and w/ co-morbidities
- lymphs account for 20-40% of WBC, may go unnoticed when WBC checked w/o diff
- Primary- recurrent infxns in kids, CVID in adults
- Secondary-⬇️production; ⬆️destruction; hiding in tissue
- Lymphopenia assc w/ ⬆️risk of sepsis
- More common in elderly and w/ co-morbidities
- lymphs account for 20-40% of WBC, may go unnoticed when WBC checked w/o diff
- Primary- recurrent infxns in kids, CVID in adults
- Secondary-⬇️production; ⬆️destruction; hiding in tissue
3/
What is the most common cause of lymphopenia in hospitalized patients?
What is the most common cause of lymphopenia in hospitalized patients?
Nice work @drmfreire + team at @JCVenterInst! 👉 They found that local #periodontal pathogen enrichment was positively associated with high systemic inflammatory profiles in patients with Systemic #Lupus Erythematosus: biorxiv.org/content/10.110…
Quote from paper 👉 “...the gut #microbiome, and recently the #oral microbiome, showed direct impact on SLE subjects, the complexity of chronic diseases such as #SLE is beyond isolated body compartments, and it requires the integration of host-microbial interactions.”
Also 👉 “At the center of #autoimmune pathogenesis, this study provides evidence that #inflammatory response to #microbiome controls the severity, and magnitude of the #SLE disease”
Important @jonykipnis statement 👉”Recent advances have directed our knowledge of the #immune system from a narrative of “self” versus “nonself” to one in which immune function is critical for #homeostasis of #organs throughout the body”:ncbi.nlm.nih.gov/m/pubmed/30504…
IMO, this shift away from “self vs. non-self” extends to “#autoimmune” disease 👉 Here, I explain how “autoantibodies” in patients w/ #SLE, #MS etc are likely created in response to persistent #pathogens (and react w/ human tissue via molecular mimicry):discoverymedicine.com/Amy-D-Proal/20…
It follows that science + #medicine + #pharmaceutical companies must move towards a new #paradigm 👉 ...in which the human #immune response is no longer treated as the enemy, but is instead regarded as our strongest ally in maintaining #microbiome + system-wide #health.
