Discover and read the best of Twitter Threads about #sle

Most recents (9)

É DAQUI A POUCO! A GRANDE ABERTURA DOS JOGOS OLÍMPICOS DE VERÃO TÓQUIO 2020!

A partir das 08h, ao vivo na Globo, SporTV e BandSports!
#Tokyo2020 #JogosOlímpicos
20 MINUTOS! Bruno e Ketleyn já estão no preparo!

📸 Christian Dawes/COB
COMEÇOU! FINALMENTE 😭😭😭😭😭
Read 101 tweets
Did you miss the talk "Panorama of #lupus in 2020?" I did yesterday for @LupusEurope?

No worries, I'm starting a #tweeter #SLE #thread so that you can pick up the slides you're interested in 👍

Check below for the SLIDES ⬇️
Slide #1
Current classification of #Lupus
Slide #2
What is #lupus #SLE
#Lupusawareness
Read 18 tweets
1/ Classic #opticneuritis is characterized by a sub-acute loss of vision in one Eye, with central #scotoma, pain on #eyemovement, positive #RAPD
- Fundus exam is usually normal
- Age range 15-45 years
2/Talking about #MOGAntibodies:
- More frequent in #pediatric population, Associated with #ADEM
- #MOG IgG serum titers depend on disease activity and is mainly from extrathecal origin, enters #CNS from systemic circulation and reaches CSF through passive diffusion or broken #BBB
Read 10 tweets
Q. What up doc. My #IBM patient doesn’t have #NT51a antibodies and my #SLE patient has #NT51a antibodies. I’m confused.
A: If only life wasn’t messy. 30 percent of #IBM patients don’t have #NT51a and false positives happen with #SLE and #Sjogrens which can cause #overlapmyositis.
Read 13 tweets
1/
Hi hi hi. We see lots of red flags on a daily basis when we review labs.

One thing we see commonly is #lymphopenia. Should we care? When can we dismiss it and when should we work it up?

Let’s find out.

#MedEd #MedTwitter #IDTwitter #Tweetorial #oncology
2/
- Lymphopenia assc w/ ⬆️risk of sepsis
- More common in elderly and w/ co-morbidities
- lymphs account for 20-40% of WBC, may go unnoticed when WBC checked w/o diff
- Primary- recurrent infxns in kids, CVID in adults
- Secondary-⬇️production; ⬆️destruction; hiding in tissue
3/
What is the most common cause of lymphopenia in hospitalized patients?
Read 14 tweets
Nice work @drmfreire + team at @JCVenterInst! 👉 They found that local #periodontal pathogen enrichment was positively associated with high systemic inflammatory profiles in patients with Systemic #Lupus Erythematosus: biorxiv.org/content/10.110… ImageImageImageImage
Quote from paper 👉 “...the gut #microbiome, and recently the #oral microbiome, showed direct impact on SLE subjects, the complexity of chronic diseases such as #SLE is beyond isolated body compartments, and it requires the integration of host-microbial interactions.”
Also 👉 “At the center of #autoimmune pathogenesis, this study provides evidence that #inflammatory response to #microbiome controls the severity, and magnitude of the #SLE disease”
Read 4 tweets
👋🏽It's May so *clears throat* lllllllleeet's get ready to #LupusAwarenessMonth

If all goes as planned (spoiler: there is no actual fucking plan) you're gonna learn something you didn't know April 30th about ✨the lupus life✨
For no reason other than I spent the day in this l'il space age container doing a pulmonary function test 🧐jealous? Let's kick it off with LUNGS:

(💜 Also fact, purple is the color o' #Lupus)
(💜If you have had Lupus lung experience, please, tell the kids how it feels)
DYK 🌞&💡are pretty damn dangerous to about 1 million Americans who have Lupus? #ThisIsLupus #LupusAwarenessMonth #LupusChat #LupusLiving
(2)
Read 8 tweets
Important @jonykipnis statement 👉”Recent advances have directed our knowledge of the #immune system from a narrative of “self” versus “nonself” to one in which immune function is critical for #homeostasis of #organs throughout the body”:ncbi.nlm.nih.gov/m/pubmed/30504… Image
IMO, this shift away from “self vs. non-self” extends to “#autoimmune” disease 👉 Here, I explain how “autoantibodies” in patients w/ #SLE, #MS etc are likely created in response to persistent #pathogens (and react w/ human tissue via molecular mimicry):discoverymedicine.com/Amy-D-Proal/20… Image
It follows that science + #medicine + #pharmaceutical companies must move towards a new #paradigm 👉 ...in which the human #immune response is no longer treated as the enemy, but is instead regarded as our strongest ally in maintaining #microbiome + system-wide #health.
Read 3 tweets

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