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Interesting study on #LDL #cholesterol via #SoybeanOil.
- Uses LDLr “knock out” mice, thus poor clearance
- Yet lower #LDL observed anyway
- Differences for “conventional” vs “modified” oils
- Conventional same plaque levels as SFA control
Ht @KCKlatt irp.nih.gov/blog/post/2022…
- Uses LDLr “knock out” mice, thus poor clearance
- Yet lower #LDL observed anyway
- Differences for “conventional” vs “modified” oils
- Conventional same plaque levels as SFA control
Ht @KCKlatt irp.nih.gov/blog/post/2022…
“After 12 weeks, the mice fed conventional soybean oil had much lower levels of VLDL and LDL cholesterol… compared to the mice fed lots of saturated fat. However, to the researchers’ surprise, the mice on those two diets had the same amount of plaque buildup in their arteries…”
Naturally, I’m especially interested in how much impact this diet had on resulting oxidative potential of newly synthesized lipoproteins and how much (or how little) of these reduced Lp-X levels could be a result of scavenger receptor removal in particular.
cc @TuckerGoodrich
cc @TuckerGoodrich
