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Amazing week for #DeepLearning in #spatial #singlecell biology, with 2🔥new Graph Neural Networks methods!
1.STELLAR🇺🇸 @jure: a cell type annotation & discovery atlas-type framework
2.NCEM🇪🇺 @fabian_theis: an approach to infer cellular communication patterns
Deep dive below🧵
1.STELLAR🇺🇸 @jure: a cell type annotation & discovery atlas-type framework
2.NCEM🇪🇺 @fabian_theis: an approach to infer cellular communication patterns
Deep dive below🧵
But first, some background.
Spatial molecular biology has actually been around since the 70s. @lpachter's wonderful book-like article "Museum of Spatial Transcriptomics" comprehensively discusses history, tech & methodology advances in the past 50 years.
nature.com/articles/s4159…
Spatial molecular biology has actually been around since the 70s. @lpachter's wonderful book-like article "Museum of Spatial Transcriptomics" comprehensively discusses history, tech & methodology advances in the past 50 years.
nature.com/articles/s4159…
Nevertheless, recent advances in single cell molecular technologies (brought by e.g. @10xGenomics & @AkoyaBio) have facilitated the high-throughout profiling of (groups of) single cells in their tissue context across embryogenesis, normal tissue development & disease progression.
