Discover and read the best of Twitter Threads about #statins
Most recents (20)
1a) Welcome to a live-tweeted, #accredited #tweetorial from @nationallipid #NLA23 in #Atlanta on advances in #hyperlipidemia management #LLT. Our expert returning faculty is Pam R. Taub, MD @PamTaubMD #cardiologist from @UCSDHealth 
1b) Dr. Taub is a clinician/scientist and is a frequent contributor to our #accredited programs. She is the founding director of the Step Family Foundation Cardiac Rehabilitation and Wellness Center at #UCSD.
#FOAMed #cardiotwitter @MedTweetorials #MedEd #lipids
#FOAMed #cardiotwitter @MedTweetorials #MedEd #lipids
2) This program is supported by an educational grant from Esperion Therapeutics & is intended for #HCPs. Statement of accreditation & faculty disclosures at cardiometabolic-ce.com/disclosures/. Earn 0.75 hr 🆓CE/#CME by following this 🧵!
Master Thread on Statins: The Four Horsemen
1) How statins nuke your mitochondria
2) How statins cause T2DM
3) How statins cause CVD
4) How statins cause cardiomyopathy
#statins #bigpharma
1) How statins nuke your mitochondria
2) How statins cause T2DM
3) How statins cause CVD
4) How statins cause cardiomyopathy
#statins #bigpharma
𝗦𝘁𝗮𝘁𝗶𝗻𝘀 destroy your skeletal muscle, why would they be any good for your 𝗵𝗲𝗮𝗿𝘁?
This 🧵 dives deep into mechanisms underlying statin induced cardiomyopathy.
#statins #cardiomyopathy #CHF #heartfailure #health #bigpharma
This 🧵 dives deep into mechanisms underlying statin induced cardiomyopathy.
#statins #cardiomyopathy #CHF #heartfailure #health #bigpharma
Over 64 million people suffer from heart failure worldwide.
To what extent is statin therapy contributing to the epidemic of congestive heart failure (CHF) worldwide?
Statin cardiomyopathy is a complication that can occur in 1-3% of people.
To what extent is statin therapy contributing to the epidemic of congestive heart failure (CHF) worldwide?
Statin cardiomyopathy is a complication that can occur in 1-3% of people.
M𝗶𝘁𝗼𝗰𝗵𝗼𝗻𝗱𝗿𝗶𝗮 are once again the linchpin linking statins to CHF.
Unveiling the Paradox: Do Statins Fuel the Fire of Heart Disease?
This is a deep dive 🧵into the mechanistic relationship between statins and coronary heart disease.
#statins #CVD #heartdisease #cholesterol #mitochondria
This is a deep dive 🧵into the mechanistic relationship between statins and coronary heart disease.
#statins #CVD #heartdisease #cholesterol #mitochondria
The ‘bad & good cholesterol hypothesis’ has lost its foundation.
Although lowering the LDL-C/HDL-C ratio is possible with drugs such as statins, this is not effective in preventing cardiovascular disease (CVD).
Although lowering the LDL-C/HDL-C ratio is possible with drugs such as statins, this is not effective in preventing cardiovascular disease (CVD).
Proxy measurements such as LDL-C are a breeding ground for scientific arrogance.
Does the measurement really mean what you think it means?
Have you looked into the assumptions that connect the proxy and the real thing?
Let's dig in.
Does the measurement really mean what you think it means?
Have you looked into the assumptions that connect the proxy and the real thing?
Let's dig in.
Statins, given like Halloween candy to those with >10% risk of CVD, can cause insulin resistance & diabetes.
A prime example of "double think".
This 🧵 explores how statins impede insulin sensitivity & damage our pancreas.
#statins #diabetes #T2DM #CVD #cholesterol
A prime example of "double think".
This 🧵 explores how statins impede insulin sensitivity & damage our pancreas.
#statins #diabetes #T2DM #CVD #cholesterol
Let's start off by reminding ourselves that diabetes and the broader category of metabolic syndrome is one of the leading risk factors for CVD.
Any drug that claims to be protective of CVD, should not be impeding insulin sensitivity.
Any drug that claims to be protective of CVD, should not be impeding insulin sensitivity.
Statins are associated with increased incidence of T2DM, 10-28% in some studies.
One way this happens is by a reduction in insulin secretion - a hormone that facilitates glucose uptake from the bloodstream into cells.
One way this happens is by a reduction in insulin secretion - a hormone that facilitates glucose uptake from the bloodstream into cells.
Statins are nuking your mitochondria.
This 🧵explores how statins impact our metabolic pathways and how this relates to the side-effects people experience.
#Statins #Mitochondria
This 🧵explores how statins impact our metabolic pathways and how this relates to the side-effects people experience.
#Statins #Mitochondria
Statins act by reversibly and competitively inhibiting HMG-CoA reductase, a key enzyme in the mevalonate pathway of which cholesterol is a final product.
Cholesterol acts as an intermediate for steroid hormones, bile acids and vitamin D, CoQ10 and is crucial to the integrity of all cell membranes.
This partly explains the plethora of statin-associated symptoms (SAS) that manifest in up to 30% of patients.
This partly explains the plethora of statin-associated symptoms (SAS) that manifest in up to 30% of patients.
🧵 Thread on my statin research 👇🏼
Our analysis in @JAMAInternalMed
21 statin trials, 143,532 participants
The benefits of #statins were minimal & most trial participants who took statins, derived no clinical benefit.
Reducing LDL-C with statins showed an inconsistent/weak… twitter.com/i/web/status/1…
Our analysis in @JAMAInternalMed
21 statin trials, 143,532 participants
The benefits of #statins were minimal & most trial participants who took statins, derived no clinical benefit.
Reducing LDL-C with statins showed an inconsistent/weak… twitter.com/i/web/status/1…
We respond to a critique by @PeterAttiaMD of our systematic review and meta analysis of #statin trials
tinyurl.com/rssdns32
tinyurl.com/rssdns32
Proposed guidelines in the UK recommend #statins to all adults if “the person is happy to take a statin”.
Here’s why it’s a bad idea 👇🏼
tinyurl.com/254987zj
Here’s why it’s a bad idea 👇🏼
tinyurl.com/254987zj
This #WomensHistoryMonth, let's celebrate the remarkable contributions of #WomenInScience! 👩🔬
Help us recognize their achievements by joining our #NameAFemaleScientist campaign.
👉 Follow us @GeneticSystems as we'll be featuring one #femalescientist each week in March.
Help us recognize their achievements by joining our #NameAFemaleScientist campaign.
👉 Follow us @GeneticSystems as we'll be featuring one #femalescientist each week in March.
#NameAFemaleScientist — Meet #MarthaChase with her groundbreaking work on DNA that challenged the prevailing theory at the time that proteins were genetic material.
Her work laid the foundation for further research into the role of DNA in inheritance and genetic disorders.
Her work laid the foundation for further research into the role of DNA in inheritance and genetic disorders.
#NameAFemaleScientist — Did you know that the key to understanding the link between diet and heart disease was unlocked by a pioneering African-American biochemist named Marie Maynard Daly?
We have responded to a critique of our 2022 analysis on statins (published in @JAMAInternalMed)
The critique was written by physician, podcaster @PeterAttiaMD
Join in the #statin discussion on Substack 👇👇
maryannedemasi.substack.com/p/response-to-… @pbyrne82 @mjones110164 @DrPaulMason
🧵👇
The critique was written by physician, podcaster @PeterAttiaMD
Join in the #statin discussion on Substack 👇👇
maryannedemasi.substack.com/p/response-to-… @pbyrne82 @mjones110164 @DrPaulMason
🧵👇
Too often, statin advocates will communicate a drug’s relative risk reduction (impressive number), without quoting the absolute risk reduction (trivial number), a practise we consider unethical (see graph)
The FOURIER trial was cited as evidence of benefit but it did not show a mortality benefit. In fact, there were more cardiovascular deaths and total deaths in the group taking the PCSK9 inhibitors compared to placebo, albeit not statistically significant.
Follow this #CardioTwitter #Thread
to get an overview of ALL
🚨#ESCcongress #HotLineSessions🚨
Including:
➡️14 #OnePager #CongressCards
➡️Links to on-demand stream
➡️Jorunal weblinks
➡️Hashtag of the author/presenter
PART 2 ⬇️
to get an overview of ALL
🚨#ESCcongress #HotLineSessions🚨
Including:
➡️14 #OnePager #CongressCards
➡️Links to on-demand stream
➡️Jorunal weblinks
➡️Hashtag of the author/presenter
PART 2 ⬇️
6.1/ #eBRAVE-AF - Smartphone-based #AF screening.
📕🔗: nature.com/articles/s4159…
On-demand ESC 📺: bit.ly/3Qc6SYp
#ESCcongress
📕🔗: nature.com/articles/s4159…
On-demand ESC 📺: bit.ly/3Qc6SYp
#ESCcongress
Join us tomorrow for the launch of a new #accredited #tweetorial on the primary care management of #hyperlipidemia covering the relationship between #LDL_C & major #CV events, CV risk categories, recommended LDL-C treatment goals, & oral therapeutic options for lipid-lowering
1) Welcome to a new #tweetorial on the primary care management of #hyperlipidemia. Our returning @cardiomet_CE expert author is dedicated #SoMe education advocate Kevin Fernando, FRCGP FRCP Edin, FAcadMEd MSc Diabetes @drkevinfernando
2a) This is the next instalment of @cardiomet_CE's 10-part #tweetorial foundational series on #lipid management! It is accredited for #CME/CE and intended for #physicians #physicianassociates #nurses #nursepractitioners #pharmacists.
#FOAMed @MedTweetorials #cardiotwitter
#FOAMed @MedTweetorials #cardiotwitter
THREAD: Online Portraits for BC family physicians
1/7 UBC’s Therapeutics Initiative now has Online #PrescribingPortraits: ti.ubc.ca/portrait
✅ Timely evidence
✅ Personalized, confidential prescribing data
✅ Recommendations to support
#BetterPrescribing & #BetterHealth
1/7 UBC’s Therapeutics Initiative now has Online #PrescribingPortraits: ti.ubc.ca/portrait
✅ Timely evidence
✅ Personalized, confidential prescribing data
✅ Recommendations to support
#BetterPrescribing & #BetterHealth
2/7 Why have a #PrescribingPortrait?
"How do I prescribe compared to others or to evidence standards?"
✅Portrait does NOT tell individual doctors how to practice
✅Portrait DOES promote optimal prescribing based on best available evidence
More here: ti.ubc.ca/portrait
"How do I prescribe compared to others or to evidence standards?"
✅Portrait does NOT tell individual doctors how to practice
✅Portrait DOES promote optimal prescribing based on best available evidence
More here: ti.ubc.ca/portrait
3/7 BC family physicians: How do you prescribe ACEIs and ARBs for #hypertension?
✅Register for your Online #PrescribingPortrait: ti.ubc.ca/portrait
✅View a sample portrait on prescribing of antihypertensives: ti.ubc.ca/2022/01/28/ace…
#BetterPrescribing #MedEd
✅Register for your Online #PrescribingPortrait: ti.ubc.ca/portrait
✅View a sample portrait on prescribing of antihypertensives: ti.ubc.ca/2022/01/28/ace…
#BetterPrescribing #MedEd
9) Many risk factors modulate the propensity of LDL-C to traverse the endothelium and enter the arterial intima. See 🔓academic.oup.com/eurheartj/arti….
10) It now appears that the passage of #LDL into the #intima is not a merely passive process whereby the concentration in blood & the permeability of the endothelium determine LDL accumulation.
11) It’s #Transcytosis (an active process), through a vesicular pathway involving #caveolae, scavenger receptors (#SRB1) and activin like receptor kinase 1 (#ALK1). Hence for a given blood level of LDL-C the amount of atherosclerosis is variable.
1) Welcome to @cardiomet_CE's new series on #lipid management! This is a 10-#tweetorial program, all #accredited, that will cover it all. Our first expert author is Paul Thompson MD @PaulDThompsonMD, esteemed #cardiologist from @hartfordhosp @UConn Med & now @MGHHeartHealth !
2) This #tweetorial, accredited for #CME/CE and intended for #physicians #physicianassociates #nurses #nursepractitioners #pharmacists is supported by an educational grant from Esperion Therapeutics. See faculty disclosures at cardiometabolic-ce.com/disclosures/.
3) @PaulDThompsonMD took on education re mechanisms & use of ezetimibe & bempedoic acid. He proposes a case: 45 ♂️ w/history of inferior wall #MI treated with primary angioplasty.
1) Welcome to @cardiomet_CE's series on #lipid management! This is a 10-#tweetorial program, all #accredited, that will cover IT ALL. The expert author for this module is Robert Giugliano MD @ @rgiugliano, renowned #cardiologist from @BrighamWomens & @harvardmed !
2) This #tweetorial, accredited for #CME/CE and intended for #physicians #physicianassociates #nurses #nursepractitioners #pharmacists is supported by an educational grant from Esperion Therapeutics. See faculty disclosures at cardiometabolic-ce.com/disclosures/.
3) @rgiugliano is going to discuss care of patients taking #statins who still have residual atherosclerotic cardiovascular disease #ASCVD risk.
THREAD: Dr. John Mandrola: “The more you see, the harder the medicine gets”
1/7 Some new views on legacy prescriptions: Beta-blockers, ASA & #statins by Dr. John Mandrola
(based on @drjohnm presentation hosted by @drug_evidence Oct 17, 2020: bit.ly/32fsPiA)
#MedED
1/7 Some new views on legacy prescriptions: Beta-blockers, ASA & #statins by Dr. John Mandrola
(based on @drjohnm presentation hosted by @drug_evidence Oct 17, 2020: bit.ly/32fsPiA)
#MedED
2/7 Example 1: Beta blockers in heart failure 💊♥️
Observational studies suggest beta-blockers for heart failure tx beyond 3 years are NOT associated with beneficial outcomes 😯
These findings challenge current recommendations: bit.ly/3acX9P7
#MedEd #deprescribing
Observational studies suggest beta-blockers for heart failure tx beyond 3 years are NOT associated with beneficial outcomes 😯
These findings challenge current recommendations: bit.ly/3acX9P7
#MedEd #deprescribing
3/7 Ex. 2: How about beta blockers to treat MIs, looking at research from pre-reperfusion & reperfusion eras?
Large meta-analysis of about 60 trials, with > than 100,000 pts found NO difference from using beta blockers in the reperfusion era: bit.ly/3dfvn6u
#MedEd
Large meta-analysis of about 60 trials, with > than 100,000 pts found NO difference from using beta blockers in the reperfusion era: bit.ly/3dfvn6u
#MedEd
A tweet thread on AYUSH.
I think these traditional medicine systems are here to stay. They are of course pure junk, totally unscientific, snake-oil, voodoo medicine.. call it whatever pejorative term you like.. but they are here to stay.
Why are they here to stay?
I think these traditional medicine systems are here to stay. They are of course pure junk, totally unscientific, snake-oil, voodoo medicine.. call it whatever pejorative term you like.. but they are here to stay.
Why are they here to stay?
Well they are here to stay quite simply because many many people have faith in them. The source of this faith and whether it is faith backed by research is debatable but the fact is people have faith in them. Mainly upper caste Hindus when it comes to Ayurveda,
But homeopathy, Unani and Siddha have their own adherents.China is promoting its #TCM - traditional Chinese medicine and the English speaking world has its #AlternativeMedicine movement. On TCM see: economist.com/leaders/2017/0…
‘Although proportionately scarce, exercise may paradoxically trigger sudden cardiac arrest in individuals with #cardiovascular disease (CVD), particularly those who were previously sedentary or have advanced CVD.’
‘In parallel with the drive to promote #exercise in all individuals, physicians will be confronted with an increasing number of enquiries from individuals with established risk factors for coronary artery disease or established CVD about participation in exercise‘
‘Such consultations need to strike a balance between the multiple benefits of #exercise, the small risk of sudden death, and the patient’s goals for cardiorespiratory fitness & ongoing participation in relatively strenuous exercise following a #cardiovascular diagnosis.’
No benefit from #statins in patients with a #CAC score of zero
#ThePowerOfZero by #YesCCT shown again @JACCJournals by @lesleejshaw
@Heart_SCCT @AChoiHeart @khurramn1 @ghoshhajra
@MichaelJBlaha @RonBlankstein @ErinMichos @DrMarthaGulati @gina_lundberg @ChinnaiyanMD
#ThePowerOfZero by #YesCCT shown again @JACCJournals by @lesleejshaw
@Heart_SCCT @AChoiHeart @khurramn1 @ghoshhajra
@MichaelJBlaha @RonBlankstein @ErinMichos @DrMarthaGulati @gina_lundberg @ChinnaiyanMD
Big win for #CAC in 2018 Cholesterol Guidelines just published @CircAHA
#CAC is now recommended for risk reclassification in low & intermediate risk patients to guide decision making for statin therapy
ahajournals.org/doi/10.1161/CI…
@AHAMeetings @MichaelJBlaha @ASPCardio @AHAScience
#CAC is now recommended for risk reclassification in low & intermediate risk patients to guide decision making for statin therapy
ahajournals.org/doi/10.1161/CI…
@AHAMeetings @MichaelJBlaha @ASPCardio @AHAScience
1| Good #cardiotwitter on #SCOTHeart. Others have tweeted reasons y believable. Here is my reply tweetorial
@khurramn1 @AChoiHeart @MarcDweck @JWeirMcCall @rwyeh @drjohnm @venkmurthy @DavidLBrownMD @RogueRad
#ESCCongress
Linking my original tweetorial:
@khurramn1 @AChoiHeart @MarcDweck @JWeirMcCall @rwyeh @drjohnm @venkmurthy @DavidLBrownMD @RogueRad
#ESCCongress
Linking my original tweetorial:
2| Let's start with MI def. Billing codes less accurate than adjudicated MI outcomes, yes? Could be nondiff misclassification which bias to null. But could also be diff w/ ascertainment bias (look harder, anchoring) knowing CCTA result, since 2/3rds normal or nonobstruct.
3| It is conjecture. But basis of clinical reasoning is to factor in test results. The posterior probability for this theory moves up much higher when we try to figure out by what mechanism did a diagnostic testing strategy lead to better outcomes, since the radiation did zilch
