Discover and read the best of Twitter Threads about #structuralbiology

Most recents (4)

🤩 - Work on related to #COVID2019 is moving fast!

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Inhibition of SARS-CoV-2 infection (previously 2019-nCoV) by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion
biorxiv.org/content/10.110… S. Xia et al., “Inhibition ...
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Alright, big picture. What does this bad boi look like?

The spike protein is key in infection, we'll look a bit closer. Montserrat Bárcena et al., ...
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The study of the spike was just released in the post-fusion state. Note that unlike the previous cartoon for mouse hepatitis virus, #SARSCOV2 is pleomorphic, with an average diameter ~120 nm. C. Liu, Y. Yang, Y. Gao, C....
Read 8 tweets
1/ It's been a very busy few weeks in the Walsh group @diamondLightSou but extremely happy to announce that in collaboration with Frank von Delft group’s at Diamond we have been able to perform a full X-ray fragment based drug discovery experiment on the SARS-CoV-2 main protease
2/ We have released all data from this work here: diamond.ac.uk/covid-19/for-s… #covid19 #SARS_COV_2 #DrugDiscovery #AntiviralDrugs #structuralbiology #crystallography #cryoEM #nmr We will update data as its generated to accelerate drug development to combat #COVID19 @JeremyFarrar
3/ This has been an amazing team effort involving on the science side my group (Petra Lukacik, Claire Strain-Damerell & David Owen) and Frank von Delft's XChem Team (Primarily Alice Douangamath, Daren Fearon) and Ailsa Powell from the @DiamondILO @EJShotton team
Read 25 tweets
Hello, I am Edna Matta. I was born in #Ibague, known as #Colombia’s #CityofMusic. A beautiful place near snow-covered volcanos (Ruiz, Santa Isabel and Tolima), large expanses of paramo forest, lakes and streams where a diverse array of animal and plant species coexist
My story starts with #powerful, #strong #women in my #family. I was the third of 4 children and my mom #firstMentor had to raise us practically alone, since my father had to work in a different city, 20h away by car
My mom is a very #strong #woman that taught me #values, to #workhard and to be #self-sufficient #StrongWomen #StrongFamily
@IWS_Network #VoicesIWS /1
Read 36 tweets
Second presentation on #ResearchMisconduct Alexander Wlodawer looking in detail at careless and rare fake structures in Crystallography and CryEM @FEBSnews
Wlodawer: several examples of structures deposited but not published, even many years later #ProteinStructure
Wlodawer: most notorious case of outright #Fabrication H.M. Krishna Murthy from University of Alabama retractionwatch.com/2018/04/10/inf…
Read 10 tweets

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