Discover and read the best of Twitter Threads about #synaptic
Most recents (3)
How do the hundreds of genetic risk-factors for #Schizophrenia actually lead to disease? New work medrxiv.org/content/10.110… from @manoliskellis illuminates the #SingleCell landscape of #Brains from patients with #Schizophrenia and their healthy counterparts🔬🧠🧵1/10
Combining single-nuclear RNA-Seq @10xGenomics, barcode #ing, and multi-level cell-state decomposition, first author Brad Ruzicka et al. identify 20 cell types in the prefrontal cortex of 24 patients with #Schizophrenia and 24 controls 2/10 
While most of these #cells have been described before, what's powerful about the approach is that we can now ask: are there specific cell-types that are increased or decreased in numbers in #Schizophrenia patients compared to healthy individuals (great study design) 3/10
Team tests hypothesis that #FMT from aged donor mice into adult recipients cld impact #brain functions associated w/ #aging 👉 Find that FMT from aged donors led to impaired spatial learning and memory in adult recipients: biorxiv.org/content/10.110…
2/ FMT from aged mice also modulated expression of a variety of proteins implicated in maintenance of #synaptic plasticity + neurotransmission in the #hippocampus☝️and #microglia cells of the hippocampus fimbria acquired an aging-like phenotype
3/ The trends must be replicated/tested in humans! 👉 But, it makes my long-held contention that the #microbiome is involved in #aging processes less “crazy”😉 For more background check out this webinar I did on the topic w/ @mike_lustgarten + @subC0smos:
Hello #dendrites friends! Check out our new paper, published at @NatureComms : "Challenging the point neuron dogma: FS basket cells as 2-stage neural networks. nature.com/articles/s4146…
Briefly, we predicted through #computational simulations that the #dendrites of #Fast_spiking #interneurons in #Hippocampal #CA3 and #PFC areas come in two #nonlinear flavors: Supralinear and sublinear!
This bimodal nonlinear behavior is determined by differences in the morphology (volume) of the dendritc branches. These differences can causally enable or prohibit the existence of #sodium_spikes. Interestingly, both types coexist in all model neurons tested!
