Discover and read the best of Twitter Threads about #t1114
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WHAT IS THE RISK CLASSIFICATION OF THE t(11;14) in MM?
This has been a long-debated question and probably asked in the wrong way. I have always had a special interest in the t(11;14) and want to tell a story and how it relates to venetoclax.
#mmsm #ASH19
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This has been a long-debated question and probably asked in the wrong way. I have always had a special interest in the t(11;14) and want to tell a story and how it relates to venetoclax.
#mmsm #ASH19
1/x
In 1998 we reported the t(11;14) was a poor prognostic marker (only translocation visible in karyotypes). We were seeing the effect of abnormal karyotypes- more growth and tumor burden. @VincentRK
onlinelibrary.wiley.com/doi/full/10.10…
ncbi.nlm.nih.gov/pubmed/10459351
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onlinelibrary.wiley.com/doi/full/10.10…
ncbi.nlm.nih.gov/pubmed/10459351
2/x
That year I convinced M Gertz to send me to Leiden, Netherlands to study t(11;14) via fiber-FISH- most elegant FISH assay. Only achievable by the great Dutch masters. At my return M Kuehl said “stop wasting your time & start doing interphase FISH.” Best advice!
@MorieGertz
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@MorieGertz
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