Discover and read the best of Twitter Threads about #taskoptimization
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How useful is a connectome? We show that you can predict quite a bit about the neural activity of a circuit from just measurements of its connectivity. Led by star graduate student @lappalainenjk, collaboration with @jakhmack. #connectome biorxiv.org/cgi/content/sh… 1/n 
How much does a connectome tell you about neural computations? This has been hotly debated (e.g. @SebastianSeung @TonyMovshon
scientificamerican.com/article/c-eleg… )?
Tricky because you don’t know much about single neuron + synapse dynamics, neuromodulation, ... ! 2/n
scientificamerican.com/article/c-eleg… )?
Tricky because you don’t know much about single neuron + synapse dynamics, neuromodulation, ... ! 2/n
Here we show that you can predict neural activity from neural connectivity measurements-- provided you can guess what the network is supposed to do. With the weight matrix essentially given by the connectome, we use #taskoptimization to estimate single neuron parameters. 3/n
