Discover and read the best of Twitter Threads about #tbtwebinar
Most recents (2)
#TBTWebinar is back ‼️
🥼 @MPishvaian @BreastCancerMD1 @Latinamd @BenWestphalen
#CME🔗 bit.ly/3vdXBb4
Pretest 👉 bit.ly/3rYNZir
Claim credit 👉 bit.ly/3ljVVXM
Supported by AstraZeneca Pharmaceuticals & Daiichi Sankyo, Inc
twitter.com/i/broadcasts/1…
🥼 @MPishvaian @BreastCancerMD1 @Latinamd @BenWestphalen
#CME🔗 bit.ly/3vdXBb4
Pretest 👉 bit.ly/3rYNZir
Claim credit 👉 bit.ly/3ljVVXM
Supported by AstraZeneca Pharmaceuticals & Daiichi Sankyo, Inc
twitter.com/i/broadcasts/1…
#TumorBoardTuesday HER2 #TBTWebinar 🔑
➡️HER2 activity requires receptor dimerization
✅HER1 = EGFR
✅HER3, HER4
➡️HER2 is frequently overexpressed in multiple cancers
✅Protein⬆️due to gene🧬 amplification
✅Constitutive activation due to activating🧬mutation
➡️HER2 activity requires receptor dimerization
✅HER1 = EGFR
✅HER3, HER4
➡️HER2 is frequently overexpressed in multiple cancers
✅Protein⬆️due to gene🧬 amplification
✅Constitutive activation due to activating🧬mutation
#TumorBoardTuesday HER2 #TBTWebinar 🔑
➡️HER2 (ERBB2) alterations occur in multiple cancer types
✅Breast Ca 25%
✅Gastric Ca 22%
✅GE jxn Ca 32%
✅CRC 5%
✅Lung Ca 6 to 30%
✅Biliary Ca 5 to 20%
🤔There is some disease specificity re: overexpression vs activating🧬mutation
➡️HER2 (ERBB2) alterations occur in multiple cancer types
✅Breast Ca 25%
✅Gastric Ca 22%
✅GE jxn Ca 32%
✅CRC 5%
✅Lung Ca 6 to 30%
✅Biliary Ca 5 to 20%
🤔There is some disease specificity re: overexpression vs activating🧬mutation
#TBTWebinar w/ @MPishvaian, @PancPathologist, @BreastCancerMD1, & Emanuel Petricoin
#CME🔗 bit.ly/3E7Crgu
Pretest bit.ly/3lkw2r0
Claim credit bit.ly/3ljVVXM
Supported by AstraZeneca Pharmaceuticals & Daiichi Sankyo, Inc.
twitter.com/i/broadcasts/1…
#CME🔗 bit.ly/3E7Crgu
Pretest bit.ly/3lkw2r0
Claim credit bit.ly/3ljVVXM
Supported by AstraZeneca Pharmaceuticals & Daiichi Sankyo, Inc.
twitter.com/i/broadcasts/1…
#TumorBoardTuesday
HER2 #TBTWebinar 🔑
HER2 (ERBB2) is frequently altered in cancer
(Breast, Lung, Gastric, Biliary, CRC)
Marked by⬆️expression from🧬amplification
Also⬆️activity due to a🌟constitutively active🧬mutation
🤔1⃣of a few🎯molecular drivers of aggressive cancer
HER2 #TBTWebinar 🔑
HER2 (ERBB2) is frequently altered in cancer
(Breast, Lung, Gastric, Biliary, CRC)
Marked by⬆️expression from🧬amplification
Also⬆️activity due to a🌟constitutively active🧬mutation
🤔1⃣of a few🎯molecular drivers of aggressive cancer
#TumorBoardTuesday
HER2 #TBTWebinar 🧐
➡️HER2 (ERBB2) testing & cut-offs varies between disease types
➡️IHC, FISH/CISH, & NGS can be used
➡️🧐Importantly, even HER2-low expression tumors may still benefit from emerging HER2-targeted antibody-drug conjugates🎯
HER2 #TBTWebinar 🧐
➡️HER2 (ERBB2) testing & cut-offs varies between disease types
➡️IHC, FISH/CISH, & NGS can be used
➡️🧐Importantly, even HER2-low expression tumors may still benefit from emerging HER2-targeted antibody-drug conjugates🎯
