Discover and read the best of Twitter Threads about #tdlus
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1/🧵We developed new in vivo #ILC models injecting intraductally ER+ #ILC lines and freshly dissected ER+ ILC tumors @EmboMolMed embopress.org/doi/full/10.15… 
2/🧵#ILC cells establish themselves at the ductal tips #microenvironment and form grape-like structures reminiscent of #TDLUs of the human breast.
3/🧵We show that in these models, the tumor cells grow slowly, invade forming hILC histologies, and metastasize in a similar way as they do in patients in clinical relevant organs including ovaries, brain-meninges, adrenal gland, GI tract, liver, and lung.
