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Have you heard about Revio by @PacBio at #ASHG22? It is such an amazing platform, 4x30-fold HiFi human genomes every 24 hours. Let me show you what it took to get this bioinformatics performance on the instrument. A thread on CCS GPU acceleration and DeepConsensus productization. 
The team behind CCS has been working hard for the past years to reduce runtime massively for the initial SQIIe and subsequent releases. We pulled all tricks to get the CPU code as fast as possible, but Revio is a completely different beast. Generating 90Gb HiFi per SMRT Cell 25M!
The polish algo in CCS is an HMM, filling out matrices at its core. The nature of its operations makes an efficient GPU implementation challenging. We’ve ported it completely onto @nvidia GPUs and achieved a 10x speedup over a dual 64c AMD EPYC, easily the fastest HMM on GPU.
