Discover and read the best of Twitter Threads about #tfmlab
Most recents (3)
Hello!
📢A new paper in which I collaborated with the group of @Rocha_Lab is now available in @PNASNews !!!
📰pnas.org/doi/10.1073/pn…
1/13- I always thought that synthetic hydrogels were relatively limited in terms of how physiologically representative they are.
📢A new paper in which I collaborated with the group of @Rocha_Lab is now available in @PNASNews !!!
📰pnas.org/doi/10.1073/pn…
1/13- I always thought that synthetic hydrogels were relatively limited in terms of how physiologically representative they are.
2/13 - Synthetic hydrogels are typically linear elastic, which is cool, because it makes my life easier while doing Traction Force Microscopy (TFM) on them 🤓... but they don't display strain stiffening characteristics as they are non-fibrous.
3/13 - 🛠️Cells in natural hydrogels, like collagen, reorient fibers around them, and they can mechanically communicate with other cells that are at a certain distance from them by remodeling and stiffening the matrix in their surroundings
But it turns out that I was wrong...
But it turns out that I was wrong...
Last April I defended my #PhD at @KU_Leuven, in which I developed ways of looking at the #Force within your cells...
(1/20) 🧵In this #ThesisThread I will tell you exactly how I did it...
(1/20) 🧵In this #ThesisThread I will tell you exactly how I did it...
(2/20) No, at least in our galaxy, our cells do not have #midichlorians. But all ~30 trillion cells of your body are able to:
🔍Change their behavior if they #feel changes in the forces around them...
💪Exert #forces to move or to explore the environment
🔍Change their behavior if they #feel changes in the forces around them...
💪Exert #forces to move or to explore the environment
(3/20) Let me give you an example:
🚀When astronauts spend time in space, their bones become weaker! This means that the cells of their bones take a decision when they don't feel the #gravity anymore!
If there is no need, why should cells bother and maintain bones?
🚀When astronauts spend time in space, their bones become weaker! This means that the cells of their bones take a decision when they don't feel the #gravity anymore!
If there is no need, why should cells bother and maintain bones?
Hello!
(1/7)
I'm thrilled to share my new article in @SoftXJournal !!
We present TFMLAB! An open source Matlab toolbox for 4D #TractionForceMicroscopy. We put special focus on making it accessible, even if you are not good at programming! 💻🧐
sciencedirect.com/science/articl…
🧵👇
(1/7)
I'm thrilled to share my new article in @SoftXJournal !!
We present TFMLAB! An open source Matlab toolbox for 4D #TractionForceMicroscopy. We put special focus on making it accessible, even if you are not good at programming! 💻🧐
sciencedirect.com/science/articl…
🧵👇
(2/7) There are many available open source codes to run 2D TFM, but what if you are now thinking of embedding your cells in a 3D matrix? You won't find that many #3DTFM codes out there that are easy to use without requiring you to be an expert programmer🧐💻
(3/7) Well, we have created #TFMLAB 🥳!! This Matlab toolbox integrates all the computational steps to compute active cellular forces from confocal microscopy images, including image processing, cell segmentation, matrix displacement measurement and force recovery
