Discover and read the best of Twitter Threads about #thecoronavirusbook
Most recents (3)
Those of us following #RECOVERYtrial know it’s one of the most important clinical trials for COVID-19, not just for its potential to identify new therapeutic options but also to temper the excitement over unproven therapies. 1/
My thoughts on the RECOVERY trial PRESS release on mortality benefit for COVID-19 with dexamethasone.
RECOVERY trial is a large randomized controlled trial with multiple arms. 11k+ patients and multiple treatments being evaluated. See image for therapeutics under evaluation. 2/
RECOVERY trial is a large randomized controlled trial with multiple arms. 11k+ patients and multiple treatments being evaluated. See image for therapeutics under evaluation. 2/
First, what is dexamethasone?
Dexamethasone is a corticosteroid, commonly called a steroid (not the anabolic kind). In addition to many other effects, it can reduce the inflammatory resonse caused by an out of control immune system. 3/
Dexamethasone is a corticosteroid, commonly called a steroid (not the anabolic kind). In addition to many other effects, it can reduce the inflammatory resonse caused by an out of control immune system. 3/
@ShamikaRavi We explored the possible effect of the monsoons on transmission SARS-CoV-2 in #TheCoronavirusBook. Influenza does activity does spike in the monsoon and post monsoon period in tropical countries. 1/
@ShamikaRavi Possible reasons: clustering of people indoors with increased social contact, high RH + precipitation and decreased solar radiation can prolong viron stability, lower vitamin D levels may play a role. 2/
@ShamikaRavi Let’s look at how influenza’s transmission changes with weather. First let’s distinguish between transmission patterns in temperate countries and tropical countries.
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@ICMRDELHI conducted a seroprevalence study across India. In this study, they tested people for antibodies against SARS-CoV-2. Those testing positive have already been infected (with or without symptoms). Seroprevalence studies indicate what % of the country has been infected 1/
The study had 2 parts. The first part, which has been completed, looked at the % of the general population that has been infected. The second part is ongoing and is looking at the % of the population in hot zones that has been infected. 2/
According to ICMR (and this is dependent on the accuracy of their test and the study methodology) 0.73% of the general Indian population may have been infected by SARS-CoV-2 at the time of the study. 3/
