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Lulu and Nana, humanity’s first gene-edited babies, both have some CRISPR edits in the CCR5 gene, as He Jiankui (JK) attempted. His goal was to confer HIV resistance.
Unfortunately, the editing turned out quite badly, as shown by *his own data* in *his own manuscript*. (thread)
Unfortunately, the editing turned out quite badly, as shown by *his own data* in *his own manuscript*. (thread)
2/
Here’s the first piece of evidence.
This is a Sanger sequencing chromatogram of a PCR amplicon of the CCR5 target site, using DNA from cells extracted from Lulu’s embryo prior to pregnancy.
In the manuscript, JK claims there’s a wild-type allele and a 15bp deletion allele.
Here’s the first piece of evidence.
This is a Sanger sequencing chromatogram of a PCR amplicon of the CCR5 target site, using DNA from cells extracted from Lulu’s embryo prior to pregnancy.
In the manuscript, JK claims there’s a wild-type allele and a 15bp deletion allele.
3/
Strangely, in his single public talk about Lulu and Nana in Hong Kong, JK showed the same exact data—but he mislabeled Lulu’s embryo’s edits, mixing them up with Nana’s.
JK’s manuscript (and the chromatograms) makes it clear:
Lulu = wild-type, -15bp
Nana = +1bp, -4bp
Strangely, in his single public talk about Lulu and Nana in Hong Kong, JK showed the same exact data—but he mislabeled Lulu’s embryo’s edits, mixing them up with Nana’s.
JK’s manuscript (and the chromatograms) makes it clear:
Lulu = wild-type, -15bp
Nana = +1bp, -4bp
Today is the 1-year anniversary of @antonioregalado breaking the news about Chinese scientist He Jiankui (JK) using gene-edited human embryos to establish pregnancies.
It’s time to break the silence. (thread)
technologyreview.com/s/612458/exclu…
It’s time to break the silence. (thread)
technologyreview.com/s/612458/exclu…
2/
1 year and 1 week ago, I learned that twin girls called Lulu and Nana had been born—humanity’s first gene-edited babies.
At that time, @MMarchioneAP asked me and a few other experts to assess a manuscript written by JK about the twins. I read it, and I was horrified.
1 year and 1 week ago, I learned that twin girls called Lulu and Nana had been born—humanity’s first gene-edited babies.
At that time, @MMarchioneAP asked me and a few other experts to assess a manuscript written by JK about the twins. I read it, and I was horrified.
3/
I won’t recount the circumstances under which @MMarchioneAP received the manuscript—it’s her story to tell, and she told it well at the #CRISPRStory session at #SciWri19 @ScienceWriting
@antonioregalado shared his story at the same session, too.
casw.org/newsroom-2019/…
I won’t recount the circumstances under which @MMarchioneAP received the manuscript—it’s her story to tell, and she told it well at the #CRISPRStory session at #SciWri19 @ScienceWriting
@antonioregalado shared his story at the same session, too.
casw.org/newsroom-2019/…
