Discover and read the best of Twitter Threads about #thenicotinetest
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A unifying *hypothesis* to explain the seemingly miraculous response to #TheNicotineTest and how it might prevent PEM in #LongCovid #vaccineinjured #mecfs - a root cause approach to PEM by modulation of the Default Mode Network in the brain. Very long thread incoming!🧵
DMN is activated in the ‘off setting’ - meditation, day dreaming, no chores get done, no brain trigger to adapt to environment, may relate to feeling of being unable to talk/move/ respond in a crash. DMN is deactivated during activity, action, cognitive/ exercise 
When measuring DMN, there is ‘activity’ and ‘connectivity’ to other brain parts. Both of these are altered in ME.
⬆️ connectivity at rest in ME with areas of fatigue and depression tinyurl.com/2u8chf7z
⬇️ connectivity / less coordinated during a task tinyurl.com/mseh93wy
⬆️ connectivity at rest in ME with areas of fatigue and depression tinyurl.com/2u8chf7z
⬇️ connectivity / less coordinated during a task tinyurl.com/mseh93wy
Is there a link between @remissionbiome and #TheNicotineTest? Could the DMN be a major key? Going to post some threads/ tweets here and then go off to research! Anyone who has the interest and the spoons, join in! #LongCovid #mecfs #pwME #vaccineinjured
DMN regulation in PEM/ link to the health rising article in @tessfalor ‘s *excellent* thread here
DMN regulation by nicotine
#TheNicotineTest day 96, about 3 months in. I don't generally feel like I have #LongCovid anymore, but I'm still dealing with damage done... especially in the summer heat. At the beginning of March I could barely walk 500m; now I've biked up to 15km.
Starting March 11th I did two days of half patches, then six days of full patches, 7 mg/ 24 hours of Nikofrenon brand that cost about E25 for a 14 pack on German Amazon. That week was pretty miserable: nausea, insomnia, headaches. But I started getting some energy too.
A week after I finished the patches I was doing a lot better, and a sudden transit strike meant I had to walk my son 4km to an appointment that couldn't be rescheduled. And I did it! But I could feel the PEM crash coming. So I put on another patch... and it didn't hit.
1. Last year we found:
👉🏻severe B12 deficiency
✅low MMA after B12 replacement...
❌...but still elevated homocysteine
❔low-normal folate
❌no MTHFR gene variant
✅...but correction of homocysteine after folic acid supplementation
👉🏻severe B12 deficiency
✅low MMA after B12 replacement...
❌...but still elevated homocysteine
❔low-normal folate
❌no MTHFR gene variant
✅...but correction of homocysteine after folic acid supplementation
this caused confusion because there is no obvious reason why i need so much folic acid to keep my homocysteine down
turns out, choline deficiency can elevate homocysteine
ncbi.nlm.nih.gov/pmc/articles/P…
and B12 deficiency might increase choline needs leading to depletion
turns out, choline deficiency can elevate homocysteine
ncbi.nlm.nih.gov/pmc/articles/P…
and B12 deficiency might increase choline needs leading to depletion
