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INCREASING SOLUBLE FIBRIN LEVELS ARE AN EARLY WARNING INDICATOR THAT IN VIVO THROMBIN GENERATION HAS BEGUN, well before there is any other laboratory or clinical evidence of hypercoagulability. It thus informs our understanding of the very early steps in the>
sequence of events within the clotting process...Although our SF discussion...revolves primarily around the thrombotic tendency in Covid patients, it in fact is valuable in any situation involving increased thrombotic risk (liver transplant...trauma, SEPSIS... SNAKEBITE, etc.)>
Viscoelastic testing (VET)...has demonstrated hypercoagulability early in Covid Associated Coagulopathy (CAC). Additional VET studies demonstrated fibrinolytic shutdown late in a majority of severely ill Covid patients with associated elevation of D- dimer. Elevated D-dimer>
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