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I am quarantined in London, so #Tweetorial time💂♂️⏰
Should we treat subclinical hypothyroidism during pregnancy?
A tweetorial on physiology, overdiagnosis, risk stratification and treatment harms.
Do you treat subclinical hypothyroidism during pregnancy?❌✅
Should we treat subclinical hypothyroidism during pregnancy?
A tweetorial on physiology, overdiagnosis, risk stratification and treatment harms.
Do you treat subclinical hypothyroidism during pregnancy?❌✅
Subclinical hypothyroidism [⬆️TSH, ↔️FT4] occurs in ~3.5% of pregnancies.
- Short differential (fig)
- No/Mild symptomatology overlaps with pregnancy, doesn't distinguish
- Consistent associations of modestly increased risk of miscarriage, preterm birth and low birth weight.
- Short differential (fig)
- No/Mild symptomatology overlaps with pregnancy, doesn't distinguish
- Consistent associations of modestly increased risk of miscarriage, preterm birth and low birth weight.
First, how to get the diagnosis right?
- Use of the correct reference range is pivotal (grey area of figure).
So, do not use 2.5/3.0 mU/L cut-offs
Note: Any TSH above 10 mU/L = overt hypothyroidism (or lab artefact)
liebertpub.com/doi/full/10.10…
- Use of the correct reference range is pivotal (grey area of figure).
So, do not use 2.5/3.0 mU/L cut-offs
Note: Any TSH above 10 mU/L = overt hypothyroidism (or lab artefact)
liebertpub.com/doi/full/10.10…
