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Developing an #mRNA vaccine is a sure-shot way to success? No! Despite the spectacular performance of #Pfizer & #Moderna vaccines, we also have a #CureVac fiasco. We need to dig in much deeper into the intricacies of developing a highly efficacious mRNA vaccine 1/
du @BeatGlogger @higgsmag wäre das ein vorschlag für 1 gemeinsames #feedlog
wir gehen die punkte durch:
- und zeigst, was #ClemensArvay nicht korrekt auf die reihe bekommt? (so?) #CoronaViurs
#thread: "mRNA-Impfstoffe: Erste Hinweise auf Langzeitfolgen"
wir gehen die punkte durch:
- und zeigst, was #ClemensArvay nicht korrekt auf die reihe bekommt? (so?) #CoronaViurs
#thread: "mRNA-Impfstoffe: Erste Hinweise auf Langzeitfolgen"
@BeatGlogger @higgsmag 1. aussage: mRNA-impfstoffe, könnten ihr immunsystem "nachhaltig" reprogrammieren
Very cool pair of new preprints @biorxivpreprints from @barton_lab on TLR regulation by Unc93b1 - biorxiv.org/content/early/… and biorxiv.org/content/early/… Here's my summary and a couple thoughts... #TLR #CellBiology #Immunology #PreReview #ASAPBio
First one, on TLR9 regulation by Unc93b1. Triple-alanine scanning mutagenesis library revealed mutant of Unc93b1 (SKN) that abolishes TLR9 signaling, although leaves endosomal trafficking and maturation intact. Single serine mutant (S282A) is responsible for full SKN phenotype
SKN or S282A both reduce amount of TLR9 binding to CpG. Both also increase amount of TLR9 bound by Unc93b1. Other mutations in same region of Unc93b1 (loop 5) either enhance or block Unc93b1 binding but all impair TLR9 activation, with much less effect on TLR7
