Discover and read the best of Twitter Threads about #tlr4
Most recents (2)
Bizar (en onjuist) antwoord @MinVWS op kamervraag tweedekamer.nl/kamerstukken/k… vorige week:
"8. Nee, van de in Nederland gebruikte mRNA-vaccins (van de fabrikanten Moderna en Pfizer) is geen relevante demping van de immuunrespons op andere ziekten bewezen of aannemelijk." 🧵 1/
"8. Nee, van de in Nederland gebruikte mRNA-vaccins (van de fabrikanten Moderna en Pfizer) is geen relevante demping van de immuunrespons op andere ziekten bewezen of aannemelijk." 🧵 1/
Een onderzoeksgroep (o.a. Radboudumc) betwist dat:
"The BNT162b248 (Pfizer) mRNA vaccine reprograms both adaptive and innate immune responses"
"The response of innate immune cells to #TLR4 and TLR7/8 ligands was lower after BNT162b248 vaccination" medrxiv.org/content/10.110… 2/
"The BNT162b248 (Pfizer) mRNA vaccine reprograms both adaptive and innate immune responses"
"The response of innate immune cells to #TLR4 and TLR7/8 ligands was lower after BNT162b248 vaccination" medrxiv.org/content/10.110… 2/
Het omzeilen van de immuunrespons is zelfs een design feature van LNP/mRNA vaccins en in dit onderzoek wordt een demping van de immuunrespons niet uitgesloten.
At higher concentrations, both L5 and DOTAP inhibited LPS-induced TLR4 activation
3/ cell.com/molecular-ther…
At higher concentrations, both L5 and DOTAP inhibited LPS-induced TLR4 activation
3/ cell.com/molecular-ther…
Flashback: "The threat of a bioterrorist attack using Variola major, the smallpox virus, or zoonotic transmission of other poxviruses🙈 has renewed interest in understanding interactions between these viruses and their hosts." ncbi.nlm.nih.gov/pmc/articles/P…
"Following respiratory infection with vaccinia (model pathogen for pox studies), mice lacking #TLR4 signaling had greater viral replication🙊, hypothermia, and mortality than control animals."
Flash forward: "Little is known about the broad effects of the new class of mRNA vaccines, especially whether they have combined effects on innate and adaptive immune responses." medrxiv.org/content/10.110…
