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#WeekendLecture
#ISC22
Highlights
300 invited talks
Nearly 200 oral abstracts
>1000 posters
Here we review some of trials and presentation from Main Events at #ISC22
#ISC22
Highlights
300 invited talks
Nearly 200 oral abstracts
>1000 posters
Here we review some of trials and presentation from Main Events at #ISC22
#ISC22 Highlights
#RESCUE_Japan LIMIT
EVT for acute LVO with #large ischemic #Core
NIHSS>6, #ASPECT 3-5 , CT or MRI (~85%)
<6hr, or DWI/FLAIR mismatch <24hr
🚶mRS 0-3 at 90d: 31 vs 12.8%, RR 2.43🩸sICH,<48hr: 9 vs 4.9% NS
⚫️Death: 18 vs 23.5%, NS
nejm.org/doi/full/10.10…
#RESCUE_Japan LIMIT
EVT for acute LVO with #large ischemic #Core
NIHSS>6, #ASPECT 3-5 , CT or MRI (~85%)
<6hr, or DWI/FLAIR mismatch <24hr
🚶mRS 0-3 at 90d: 31 vs 12.8%, RR 2.43🩸sICH,<48hr: 9 vs 4.9% NS
⚫️Death: 18 vs 23.5%, NS
nejm.org/doi/full/10.10…
#ISC22 Highlights
#Rescue-BT EVT with or w/o #tirofiban in LVO stroke
GPIIb/IIIa-R inhibitor could ⏬reocclusion after MT
55🏥in🇨🇳AIS<24hr, no IVT, ASPECT≥6
950pts
🚶mRS at 90d: 3 vs 3
🩸sICH: 9.7 vs 6.4%, NS
⚫️Death: 18.1 vs 16.9%
Treatment effect modification in LAA subgroup
#Rescue-BT EVT with or w/o #tirofiban in LVO stroke
GPIIb/IIIa-R inhibitor could ⏬reocclusion after MT
55🏥in🇨🇳AIS<24hr, no IVT, ASPECT≥6
950pts
🚶mRS at 90d: 3 vs 3
🩸sICH: 9.7 vs 6.4%, NS
⚫️Death: 18.1 vs 16.9%
Treatment effect modification in LAA subgroup
#WeekendLecture
#HistoryofEVT
It’s no secret that #EVT for AIS has been a complete game changer for the field resulting in dramatic reduction in death & disability
Join us to explore the #history of EVT in collaboration with @SVINJournal, to celebrate the inaugural issue
#HistoryofEVT
It’s no secret that #EVT for AIS has been a complete game changer for the field resulting in dramatic reduction in death & disability
Join us to explore the #history of EVT in collaboration with @SVINJournal, to celebrate the inaugural issue
Many thanks to @Mahmoudneuro, #RaulNogueira and @DiogoHaussen whose review entitled:
👉“Tx Advancements in the Endovascular Management of Stroke” celebrates the advances in #ETV
🆓 #openaccess
✅ahajournals.org/doi/full/10.11…
👉“Tx Advancements in the Endovascular Management of Stroke” celebrates the advances in #ETV
🆓 #openaccess
✅ahajournals.org/doi/full/10.11…
1st #Fun fact: Interventional treatment of AIS dates all the way back to 1950s‼️
Sussman & Fitch reported 3 cases of IA infusion of fibrinolytics
Didn’t work 😫. Probably because they were performed in a non-hyperacute fashion
But this laid the foundation for years of refinement
Sussman & Fitch reported 3 cases of IA infusion of fibrinolytics
Didn’t work 😫. Probably because they were performed in a non-hyperacute fashion
But this laid the foundation for years of refinement
#WeekendLecture
#Tenecteplase #TNK
Part 1
✅3rd generation rtPA
🧬Targeted genetic upgrade
3 specific alterations to #alteplase molecule:
👉⬆️Half life
👉⬆️Binding affinity for #fibrin
👉⬆️Resistance to inactivation by #PAI-1
bit.ly/3pqbEb1
#Tenecteplase #TNK
Part 1
✅3rd generation rtPA
🧬Targeted genetic upgrade
3 specific alterations to #alteplase molecule:
👉⬆️Half life
👉⬆️Binding affinity for #fibrin
👉⬆️Resistance to inactivation by #PAI-1
bit.ly/3pqbEb1
#WeekendLecture
#TNK
👉⬆️T1/2 allows single bolus dosing and⬆️clot exposure to TNK
👉Higher affinity to fibrin-rich clots & + potent/faster clot #lysis vs alteplase
👉 < consumption of fibrinogen/plasminogen/ a2- antiplasmin👉⬇️systemic fibrinolytic effect👉⏬risk for bleeding
#TNK
👉⬆️T1/2 allows single bolus dosing and⬆️clot exposure to TNK
👉Higher affinity to fibrin-rich clots & + potent/faster clot #lysis vs alteplase
👉 < consumption of fibrinogen/plasminogen/ a2- antiplasmin👉⬇️systemic fibrinolytic effect👉⏬risk for bleeding
#WeekendLecture
#TNK
First analysis in stroke patients was a #dose-scalation safety study
There was no #symptomatic ICHs in dosis of 0.1-0.2-0.4mg/kg, and 15% (2 of 13) in 0.5mg/kg
No differences in clinical outcomes
bit.ly/3DNHamV
#TNK
First analysis in stroke patients was a #dose-scalation safety study
There was no #symptomatic ICHs in dosis of 0.1-0.2-0.4mg/kg, and 15% (2 of 13) in 0.5mg/kg
No differences in clinical outcomes
bit.ly/3DNHamV
Alguna de las razones que podrían explicar que Teekay Corporation #TK está cotizando en mínimos históricos:
✔️Deshacerse de su filial Teekay Offshore Partners fue positivo dado que lastraba, y mucho, la rentabilidad de la matriz.
⚠️Sin embargo de ese sector aún conserva
✔️Deshacerse de su filial Teekay Offshore Partners fue positivo dado que lastraba, y mucho, la rentabilidad de la matriz.
⚠️Sin embargo de ese sector aún conserva
3 unidades flotantes de producción, almacenamiento y descarga ("FPSO"), " Petrojarl Foinaven ", " Petrojarl Banff " y " Hummingbird Spirit ", que han seguido siendo un lastre importante para los resultados de la compañía durante bastante tiempo.
⚠️Precisamente por lo anterior,
⚠️Precisamente por lo anterior,
#TK se vio obligado a depreciar el valor de sus FPSO en casi $ 500 millones, ya que los precios del petróleo más bajos de lo esperado han llevado a cambios en los proyectados flujos de efectivo subyacentes para las unidades.
Analysis: #NYSE $TNK
Case 220 #Teekay Tankers Ltd.
DISCLAIMER: The analysis is strictly for educational purposes and should not be construed as an invitation to trade.
#TNK 1/4
Case 220 #Teekay Tankers Ltd.
DISCLAIMER: The analysis is strictly for educational purposes and should not be construed as an invitation to trade.
#TNK 1/4
Chart 1
Weekly Chart: A strong base has formed at the all time low and good buying interest has seen a brief take-over of the #Fib. 0.236 but currently trading below and finding above the old #pivot resistance 11.27. #Momentum .....
TNK 2/4
Weekly Chart: A strong base has formed at the all time low and good buying interest has seen a brief take-over of the #Fib. 0.236 but currently trading below and finding above the old #pivot resistance 11.27. #Momentum .....
TNK 2/4
..... is favouring further gains towards formidable #resistance at 47.10.A break below 5.00 will see price find #support at 3.30 - 2.90.
TNK 3/4
TNK 3/4
