Discover and read the best of Twitter Threads about #trivalent

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David R. Martinez, Ph.D.
@David_RMartinez
Our latest paper describing #universal #CoV vaccine that can protect against #MERSCoV and #SARSCoV is now out⁩ in #preprint ⁦@YaleMed⁩ ⁦

Short thread 👇🏼

“Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice” biorxiv.org/content/10.110…
We were interested in developing vaccination strategies against highly pathogenic human #coronaviruses with epidemic potential. Our previous studies, and those of others, defined the #RBD as a major target of neutralizing antibodies.
We therefore looked to #ferritin nanoparticles as a scaffold to display genetically divergent RBDs from both Group 2c merbecoviruses (#MERSCoV) and Group 2b sarbecoviruses (#SARSCoV , #SARSlike viruses, and #SARSCoV2). Our vaccines elicited broad binding antibodies in mice.
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Related hashtags

#RBD #coronaviruses #CoV #SARSCoV #MERSCoV #SARSCoV2 #nanoparticle #SARSlike #universal #ferritin #preprint #trivalent

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