Discover and read the best of Twitter Threads about #ttm2trial
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I am pleased & proud to see the #PLUStrial published in @NEJM today. It is my 10th @NEJM paper! Here’s my list of @NEJM papers and what I think they mean for clinical practice
#1: The #HEATtrial (Dec 2015) showed that using paracetamol to treat fever in ICU patients with suspected infections did not affect the number of ICU-free days. Mortality rates were similar in paracetamol & placebo-treated patients:
nejm.org/doi/full/10.10…
nejm.org/doi/full/10.10…
These data provide reassurance that if paracetamol is administered to treat fever in the setting of an infection or given for another reason to a patient who happens to have fever & infection, such as for analgesia, harm is unlikely to result.
The #TTM2trial was published today in the @NEJM
Here’s a summary of what we did, what I think the trial means, and what next.
@ttm2trial @nielsen_niklas @CritCareReviews @NEJMnejm.org/doi/full/10.10…
Here’s a summary of what we did, what I think the trial means, and what next.
@ttm2trial @nielsen_niklas @CritCareReviews @NEJMnejm.org/doi/full/10.10…
We enrolled 1900 adults with a coma after an out of hospital cardiac arrest with a presumed cardiac or unknown cause
We assigned them to hypothermia at 33°C followed by controlled rewarming OR to normothermia with early treatment of fever (body temp ≥37.8°C)
